A competitive spectrophotometric study of Eu(III) and Gd(III) complexes with adenosine 5′-triphosphate by use of a sensitive indicator ligand

Ohyoshi, Emiko; Kohata, Susumu

doi:10.1016/0162-0134(91)84068-k

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Choppin et al studied lanthanide complexation by benzoic acid and isophthalic acid and suggested that in the latter ligand, steric effects prevent simultaneous binding to both carboxylate sites. Studies on complex formation by tripositive rare earth ions with biologically important ligands are in progress because of their role in biochemical processes, and some lanthanide complexes with nucleosides/nucleotides are also available in the literature. − To the best of our knowledge, no examples of the interaction of uracil and its halo derivatives with lanthanides in the presence of benzoic acid/its derivatives are known to date. The present paper reports studies on the interaction of uracil (Ur), 5-fluorouracil (FUr), 5-chlorouracil (ClUr), and 5-bromouracil (BrUr) as one ligand and benzoic acid (OBz), 4-nitrobenzoic acid (NBz), 4-fluorobenzoic acid (FBz), 4-chlorobenzoic acid (ClBz), and 4-bromobenzoic acid (BrBz) as another ligand with Eu(III), Gd(III), and Tb(III) in 1:1:1 ratio potentiometrically at (25 ± 0.1) °C.…”

Section: Introductionmentioning

confidence: 99%

Solution Studies of Some Binary and Ternary Lanthanide Complexes

Tyagi

Kumar

2005

J. Chem. Eng. Data

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The solution studies of some binary (1:1) and ternary (1:1:1) complexes of Eu(III), Gd(III), and Tb(III) with benzoic acid/its derivatives and uracil/its halo derivatives in dioxane−water (30:70 v/v) medium (ionic strength I = 0.1 mol·dm-3 NaNO3) have been performed. The experimental pH titration data were analyzed with the help of the BEST computer program in order to evaluate the formation constants of various intermediate species formed. The stability constants of the binary (1:1) systems decrease in order of Tb(III) > Eu(III) > Gd(III). The formation constant of 1:1:1 mixed ligand complexes for Eu(III), Gd(III), and Tb(III) with benzoic acid/its derivatives as the primary ligand and uracil/its halo derivatives as the secondary ligand has also been studied. The available data suggested that the ternary complexes of Eu(III), Gd(III), and Tb(III) are more stable than the crossponding binary complexes.

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Section: Introductionmentioning

confidence: 99%

Solution Studies of Some Binary and Ternary Lanthanide Complexes

Tyagi

Kumar

2005

J. Chem. Eng. Data

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Preorganized Bis‐Zinc Phosphodiester Cleavage Catalysts Possessing Natural Ligands: A Lesson Pertinent to Bimetallic Artificial Enzymes

Worm

Chu

Matsumoto

et al. 2003

Chemistry A European J

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Two preorganized bis-zinc receptors (2 and 3) were synthesized wherein the metals were ligated with ligands present in natural phosphodiesterases: imidazoles and carboxylates. The intrametallic distance is near 4.5 A, that found in natural nucleases and other successful artificial nucleases. With only two imidazoles (2), the zinc binding affinities were not high enough to achieve cooperativity. Yet, with a third ligand, a carboxylate (3), cooperativity was found in the cleavage of HPNPP. The preorganization of 3 was achieved using a "steric gearing" strategy. The enhancement was 80-fold for cooperation between the two metals relative to a mono-metallic analogue (5). However, there was no observable enhancement in the hydrolysis of RNA using 3 relative to 5. Therefore, we conclude that placing two zinc atoms that are ligated with natural ligands at the appropriate distance for catalysis is not sufficient to enhance the cleavage of RNA, but is successful for activated RNA substrate mimics.

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The binding of Yb(III) and Gd(III) to bovin serum albumin by a competitive spectrophotometry

Ohyoshi¹,

Kohata²

1993

Journal of Inorganic Biochemistry

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A competitive spectrophotometric study of Eu(III) and Gd(III) complexes with adenosine 5′-triphosphate by use of a sensitive indicator ligand

Cited by 6 publications

References 15 publications

Solution Studies of Some Binary and Ternary Lanthanide Complexes

Solution Studies of Some Binary and Ternary Lanthanide Complexes

Preorganized Bis‐Zinc Phosphodiester Cleavage Catalysts Possessing Natural Ligands: A Lesson Pertinent to Bimetallic Artificial Enzymes

The binding of Yb(III) and Gd(III) to bovin serum albumin by a competitive spectrophotometry

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