A complete physical mapping of the vitamin D receptor gene for dental implant loss: A pilot study

Abstract

Objectives The aim of this pilot case–control study was to investigate the association of clinical variables and genetic polymorphisms in the vitamin D receptor gene (VDR) with dental implant loss. Material and Methods This study was carried out with 244 individuals with mean age 51.90 ± 11.28 (81 cases and 163 controls matched by age, sex, and smoking habit). Also, the clusterization phenomenon was investigated stratifying the sample into two groups: (a) 34 patients with multiple losses (presenting two or more lost implants) and (b) 210 without multiple losses (up to one implant loss). Sociodemographic, clinical, and periodontal parameters were analyzed. The tagSNPs in the VDR gene were analyzed by real‐time PCR. Univariate and multivariate analyses were performed (p < .05). Results Edentulism, number of implants installed, and Gingival, Plaque, and Calculus Indexes were associated with implant loss in the univariate analysis. After the multivariate analysis, the allele G of rs3782905 in the recessive model, together with number of installed implants and Gingival Index, was associated with implant failure. Conclusion It is suggested that the allele G of rs3782905 in the recessive model may be a new genetic risk marker for dental implant loss in patients who lost two or more dental implants. In addition, number of implants installed and Gingival Index were also associated. Replication is mandatory to confirm these findings, due to the modest sample size of this work.

Impact of Vitamin D on Osseointegration in Dental Implants: A Systematic Review of Human Studies

“…The studies varied in design, ranging from case reports and case–control studies to a randomized trial. Specifically, two studies were case–control [ 21 , 26 ], three were case reports [ 22 , 23 , 24 ], one was a case series [ 24 ], one a retrospective cohort study [ 25 ], and one a randomized trial [ 27 ]. This assortment of study designs reflects the multifaceted approach researchers have taken to examine the relationship between Vitamin D and dental implant osseointegration.…”

“…In terms of quality of evidence, the review found a mix. Two studies [ 21 , 26 ] from Brazil and one from Italy [ 25 ] were rated as having a medium quality of evidence. In contrast, three studies [ 22 , 23 , 24 ]—from the USA, the United Kingdom, and Germany—were categorized as low in evidence quality.…”

“…The participant groups varied significantly across the studies. Alvim-Pereira et al [ 21 ] compared 137 individuals with dental implants to 70 without, while Pereira et al [ 26 ] studied 81 individuals with a Vitamin D receptor mutation against 163 controls. Kwiatek et al [ 27 ] categorized their 122 participants into three groups based on Vitamin D levels and supplementation.…”

Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review

“…The flowchart shown in Figure 1 illustrates each step in the search and screening process. The articles excluded and the reasons for their exclusion are shown in Table 1 [ 24 , 25 , 26 , 27 , 28 ]. In this review, the study by Mangano et al [ 29 ] was considered a continuation of the study by Mangano et al [ 30 ], so it was treated as a single study for purposes of data extraction.…”

Alveolar bone morphology and remodeling parameters in the sites of congenitally missing teeth. A pilot study

“…Alvim-Pereira et al 24 failed to find any association between failure of osseointegration around implants and the genotypic variation of VDR gene which didn't agree with the present findings. In 2019, Pereira et al 25 suggested a possible role of allele G of rs3782905 of VDR in the recessive model may in dental implant loss in patients who lost two or more dental implants. The authors recommended further replication of their study to confirm their findings.…”