Information on surface tension is necessary for modeling boiling processes in nanofluids. It was shown that the problem of predicting the surface tension of complex thermodynamic systems, such as nanofluids, remains outstanding. It should be noted that the surface tension of liquids and the saturated vapor pressure are due to a specific intermolecular interaction in the region of spatial heterogeneity of the substance (surface layer). Moreover, the compositions of the surface layer of nanofluid and its liquid phase are not equal. The presence of nanoparticles in the base fluid affects the composition of the surface layer of liquids. However, there are no methods for determining the composition of the surface layer of nanofluids and this fact complicates establishing the dependence of the surface tension on the state parameters of nanofluids. It should be mentioned that the number of possible methodological errors in measurements of the saturated vapor pressure of nanofluids is significantly lower than for the surface tension measurements. Therefore, in the development of models for predicting the surface tension, scientific and practical interest has establishing the relationship between the surface tension and the saturated vapor pressure of nanofluids. In the presented work, we consider the nanofluids of isopropanol/Al 2 O 3 nanoparticles and o-xylene/fullerenes C 60 . Saturated vapor pressure and surface tension of nanofluids of isopropanol/Al 2 O 3 nanoparticles have been studied in the temperature range 293 -363 K and concentrations of Al 2 O 3 nanoparticles 0-8.71 g/kg. Measurement of saturated vapor pressure and surface tension of nanofluids of o-xylene/fullerenes C 60 have been performed in the temperature range 283 -348 K and the concentration of C 60 0-7.5 g/kg. It is shown that additives of Al 2 O 3 nanoparticles and fullerenes C 60 lead to a decrease in the surface tension and increase in the saturated vapor pressure. It is shown that there is a universal dependence between the reduced surface tension and saturated vapor pressure for the researched nanofluids.