A complex relation between depression and multiple sclerosis: a descriptive review

Corallo, Francesco; Buono, Viviana Lo; Genovese, Roberto; Palmeri, Rosanna; Cara, Marcella Di; Rifici, Carmela; Sessa, Edoardo; D’Aleo, Giangaetano; Galletti, Francesco; Marıno, Silvia

doi:10.1007/s10072-019-03889-1

Cited by 21 publications

(14 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study is also limited by the lack of information on the levels of depression, anxiety, and stress prior to COVID-19 outbreak. Therefore, it is not clear that the difference between MS and HC in DASS score is related either to the COVID-19 pandemic or MS burden [58]. A limited number of migraine patients who participated in this study are another limitation.…”

Section: Discussionmentioning

confidence: 92%

Assessment of mental health, knowledge, and attitude of patients with multiple sclerosis and neuromyelitis optica spectrum disorder in response to 2019 novel coronavirus

2020

View full text Add to dashboard Cite

Background With the recent pandemic of the novel coronavirus disease (COVID-19), multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) patients for their compromised immune system have been in significant concern. Awareness and attitude about this virus have an important impact on infection prevention and coping with stress and anxiety. So we conducted this study to assess knowledge, attitude, and mental health status in MS and NMOSD patients within the COVID-19 pandemic. Method In this cross-sectional study, the link of Depression Anxiety Stress Scales-21 (DASS-21) and a self-administered structured questionnaire were sent through social media to MS and NMOSD patients and two control groups consisting of healthy and migraine individuals. Results A total of 223 MS patients, 41 NMOSD, 29 migraine, and 245 healthy subjects participated in this study. MS patients had higher total DASS scores compared to healthy participants (p = 0.012). There were no significant differences among the study groups regarding knowledge and attitude. In MS patients, physical comorbidity was associated with a total score of attitude (OR 1.59, 95% CI 0.53, 2.66, p = 0.004). We did not find association between other demographic and clinical variables with DASS scores, attitude, and knowledge in MS patients. Conclusion The current data highlight the necessity of attitude, knowledge, and mental health assessment among MS and NMOSD patients. Further studies in other countries need to be carried to assess these points among MS and NMOSD patients.

show abstract

Section: Discussionmentioning

confidence: 92%

Assessment of mental health, knowledge, and attitude of patients with multiple sclerosis and neuromyelitis optica spectrum disorder in response to 2019 novel coronavirus

2020

View full text Add to dashboard Cite

show abstract

“…1,2 Neuroaxonal damage, leading toward the disruption of structural and functional neuronal networks, contributes to the development and progression of irreversible disability including cognitive deterioration in patients with MS. 3,4 Widespread axonal damage and the resulting disconnection of neuronal circuits has also a prominent role in the pathogenesis of fatigue and affective symptoms such as depression. 5,6 Yet, in standard clinical care, accurate and regular cognitive and neuropsychiatric assessment is often not incorporated despite its clinical importance due to limited time and financial resources. 7 Disease activity and burden is instead approached by traditional measures such as the Expanded Disability Status Scale (EDSS), the Multiple Sclerosis Severity Score, or the Multiple Sclerosis Functional Composite, which do not sufficiently mirror cognitive and neuropsychiatric status.…”

mentioning

confidence: 99%

Serum neurofilament light chain

Aktaş

Renner

Huss

et al. 2020

Neurol Neuroimmunol Neuroinflamm

View full text Add to dashboard Cite

ObjectiveTo explore the hypothesis that serum neurofilament light chain (sNfL) indicative of neuroaxonal damage may improve precise disease profiling with regard to cognition and neuropsychiatric symptoms, we analyzed potential associations of sNfL levels with cognitive test scores, fatigue, depression, and anxiety.MethodsPatients with relapsing-remitting and secondary progressive MS (SPMS) underwent an elaborated assessment including MRI, various cognitive tests, and patient-reported outcomes. We determined sNfL levels by single molecule array (Simoa) assay. Relationships between sNfL, cognition, neuropsychiatric symptoms, and demographical data were analyzed using correlations, group comparisons, and regressions.ResultsIn 45 clinically stable patients with MS (Expanded Disability Status Scale = 2.73 ± 1.12, disease duration = 10.03 ± 7.49 years), 40.0% were cognitively impaired. Mean sNfL levels were 16.02 ± 10.39 pg/mL, with higher levels in the SPMS subgroup (p = 0.038). sNfL levels did reliably link neither with the investigated cognitive and affective parameters nor with fatigue levels. The only relationship found in a small subgroup of patients with SPMS (n = 7) with visuospatial learning (r = −0.950, p = 0.001) and memory (r = −0.813; p = 0.026) disappeared when further controlling for age, educational level, and sex.ConclusionsIn patients with stable MS at less advanced disease stages, sNfL did not convincingly relate to cognitive performance, fatigue, depression, or anxiety and thus may not serve as a surrogate biomarker for neuropsychological status in such populations.

show abstract

“…When the difference between the groups in this study is examined, we found that the MS group has a higher depression level than the control group. The current literature showed that depression in MS is seen generally higher than those of the general population [32] and other chronic diseases [33]. Researchers [10] found both female and male pwMS have higher depression levels than the control group.…”

Section: Discussionmentioning

confidence: 90%

Depression, sexual dysfunction, life satisfaction and marriage satisfaction in women with multiple sclerosis

Aydın

Önger

2022

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Background Marriage satisfaction is one of the factors that affects life satisfaction in healthy people and patients. In the current literature, it is found there is a positive correlation between marriage and life satisfaction. Many factors such as sexual dysfunction, depression and neurological disorders affect negatively marriage and life satisfactions. However, there is not enough research dealing with how multiple sclerosis (MS) affects women's marital and life satisfaction. This study aimed to examine marital satisfaction and life satisfaction of female patients with MS (pwMS) in relation to sexual dysfunction and depression. A total of 139 married women (MS Group: 81, Control Group: 58) were recruited in the study. Then both groups’ participants were requested to fill the relevant documentary; Demographic Information Form, Marital Life Scale (MLS), Life Satisfaction Scale (LSS), Arizona Sexual Experiences Scale (ASEX), and Beck Depression Inventory (BDI). Results Regarding the percentages of the relevant parameters; it was examined that 60.96% of pwMS and 62.07% of control group have depression, respectively. In addition, 89.16% of pwMS and 86.21% of control group have sexual dysfunction, respectively. Furthermore, 55.52% of pwMS and 44.83% of control group have high life satisfaction, whereas 60.24% of pwMS and 56.90% of control group have high marriage satisfaction, respectively. There was a strong positive correlation between marriage satisfaction and life satisfaction (p < 0.001) and there was a weak negative correlation between marriage satisfaction and sexual dysfunction (p < 0.001). In addition, there were weak negative correlations between marriage satisfaction and depression level (p < 0.001) and between life satisfaction and sexual dysfunction (p < 0.001), respectively. Similarly, there was a weak negative correlation between life satisfaction and depression level (p < 0.001), whereas there was a weak positive correlation between depression level and sexual dysfunction (p < 0.001). Finally, while there was no significant difference in the marriage satisfaction and sexual dysfunction between the groups in points of life satisfaction and depression level (p > 0.05). Conclusion Sexual dysfunction and depression are important problems that affect women’s marriage and life satisfaction. Sexual dysfunction is a common problem for women, regardless of MS.

show abstract

A complex relation between depression and multiple sclerosis: a descriptive review

Cited by 21 publications

References 54 publications

Assessment of mental health, knowledge, and attitude of patients with multiple sclerosis and neuromyelitis optica spectrum disorder in response to 2019 novel coronavirus

Assessment of mental health, knowledge, and attitude of patients with multiple sclerosis and neuromyelitis optica spectrum disorder in response to 2019 novel coronavirus

Serum neurofilament light chain

Depression, sexual dysfunction, life satisfaction and marriage satisfaction in women with multiple sclerosis

Contact Info

Product

Resources

About