Welcome to the wonderful world of AxiSEM3D, a flexible, high-performance computational method for solving the elastodynamic wave equation in three-dimensional, hetereogeneous media. It has been used in seismology for the Earth, the Sun, the Moon, and many of other rocky planets and moons of the Solar System. In this manual, we will explore the practicalities of using this code, touching on the mathematical aspects as relevant to the casual user, the input and output files, and pre- and post-processing. This guide is not a replacement for any of the AxiSEM3D papers, which you will find listed in the next section. Nor does it go into any detail about how to install, build, configure, or make the code as these are dealt with in a separate installation guide. However, it does contain everything to do with the scientific aspects of the code and the user interface post-installation.