A Composite Canine Model of Cirrhosis

Baddeley, Richard M.; J, Fejfar

doi:10.1097/00000658-196904000-00018

Cited by 1 publication

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References 8 publications

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“…The main reason lies in that portal pressure was temporarily elevated before the establishment of the structural changes in hepatic architecture caused by the increased resistance of portal blood flow [8,12]. Once multiple portosystemic shunts (PSS) were developed, the portal pressure rapidly returns to normal [13].…”

Section: Introductionmentioning

confidence: 99%

A Novel Canine Model of Portal Vein Stenosis Plus Thioacetamide Administration-Induced Cirrhotic Portal Hypertension With Hypersplenism

Lin

et al. 2011

Cell Biochem Biophys

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Current large animal models that could closely resemble the typical features of cirrhotic portal hypertension in human have not been well established. Thus, we aimed to develop and describe a reliable and reproducible canine cirrhosis model of portal hypertension. A total of 30 mongrel dogs were randomly divided into four groups: 1 (control; n = 5), 2 (portal vein stenosis [PVS]; n = 5], 3 (thioacetamide [TAA]; n = 5), and 4 (PVS plus TAA; n = 15). After 4-months modeling period, liver and spleen CT perfusion, abdominal CT scans, portal hemodynamics, gastroscopy, hepatic function, blood routine, the bone marrow, liver, and spleen histology were studied. The animals in group 2 (PVS) developed extrahepatic portosystemic collateral circulation, particularly esophageal varices, without hepatic cirrhosis and portal hypertension. Animals from group 3 (TAA) presented mild cirrhosis and portal hypertension without significant symptoms of esophageal varices and hypersplenism. In contrast, animals from group 4 (PVS + TAA) showed well-developed micronodular and macronodular cirrhosis, associated with significant portal hypertension and hypersplenism. The combination of PVS and TAA represents a novel, reliable, and reproducible canine cirrhosis model of portal hypertension, which is associated with the typical characteristics of portal hypertension, including hypersplenism.

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Section: Introductionmentioning

confidence: 99%

A Novel Canine Model of Portal Vein Stenosis Plus Thioacetamide Administration-Induced Cirrhotic Portal Hypertension With Hypersplenism

Lin

et al. 2011

Cell Biochem Biophys

View full text Add to dashboard Cite

show abstract

A Composite Canine Model of Cirrhosis

Cited by 1 publication

References 8 publications

A Novel Canine Model of Portal Vein Stenosis Plus Thioacetamide Administration-Induced Cirrhotic Portal Hypertension With Hypersplenism

A Novel Canine Model of Portal Vein Stenosis Plus Thioacetamide Administration-Induced Cirrhotic Portal Hypertension With Hypersplenism

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