A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery

Abstract

The aim of the study was the development of a resorbable membrane for guided bone regeneration (GBR) with improved biocompatibility, which should be stiff enough to avoid membrane collapse during bone healing. Combining a bioactive ceramic with a resorbable polymer may improve the biocompatibility and osteoconductivity of resorbable devices. The present article describes the preparation, the mechanical properties, and the in vitro degradation characteristic of a composite membrane made of poly(L, DL-lactide) and alpha-tricalcium phosphate in comparison to a membrane made of pure poly(L, DL-lactide). The tensile strength and the elastic modulus as well as the molecular weight of the membranes were measured after in vitro degradation in buffer at 37 degrees C up to 28 weeks. The initial tensile strength of the composite and the polymer membrane was 37.3 +/- 2.4 MPa and 27.7 +/- 2.3 MPa and the elastic modulus 3106 +/- 108 MPa and 3101 +/- 104 MPa, respectively. The mechanical properties remained constant up to 8 weeks and then decreased slowly until week 28. The molecular weight of both membranes decreased steadily from 170,000 D to 30,000 D. It was concluded that the mechanical requirements for a membrane for GBR were fulfilled by the composite membrane.

Mandibular Ridge Splitting and Gradual Bone Expansion Technique for Immediate Placement of Implant in the Posterior Thin Region: A Clinical Report

“…Onlay grafting with biodegradable membranes and autografts is the most frequently used technique; however, this technique involves a long ossification period, and the tendency of the graft material to resorb can easily decrease bone quality and quantity (19). Time lost and donor-side morbidity are the main disadvantages of this reconstructive approach.…”

“…Wound healing in these cases is similar to the fracture repair of bone. The gap is filled with a blood clot, which is organized and replaced with woven bone and further matures into load-bearing lamellar bone at the implant interface (19). The ridge splitting technique is used to expand the edentulous ridge for implantation or insertion of interpositional bone graft (15).…”

Creation of highly functional CO3Ap-collagen scaffold biomaterials

“…Osteoblasts could invade through the sponge bottom; however, the sponge material appeared to shrink during culture or animal experiments. First, we considered ensuring enough space in which new bone could easily form, utilizing the concept of guided bone regeneration (GBR) 16) , and we newly created a sponge reinforced with a porous HAp-frame 17) . Our concept is that sponge as cancellous bone and the frame as trabecular bone are hybridized similar to natural bone.…”

Polylactide/polycaprolactone asymmetric membranes for guided bone regeneration

“…The intensive research is being conducted to find the best solution for membranes among resorbable materials. So far numerous studies (11)(12)(13)(14)(15)(16) have specified the parameters that are key factors for guided bone regeneration materials. The most important requirement is the proper size of pores.…”