A composite sponge based on alkylated chitosan and diatom-biosilica for rapid hemostasis

Sun, Xiaoyang; Li, Jing; Shao, Kai; Su, Chang; Bi, Shichao; Mu, Yuzhi; Zhang, Kaichao; Cao, Zheng; Chen, Xiguang; Feng, Chao

doi:10.1016/j.ijbiomac.2021.05.123

Cited by 40 publications

(27 citation statements)

References 43 publications

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“…Chitosan and its derivatives exert antitumor activities and can, therefore, be potentially used in drug-delivery systems for the treatment of sarcoma ( Maleki Dana et al, 2021 ). Besides, chitosan-based nanoparticles, sponges, films, hydrogels, and scaffolds have been used for soft tissue injury treatment ( Oryan and Sahvieh, 2017 ; Hemmingsen et al, 2021 ; Rashki et al, 2021 ; Sun et al, 2021 ). Although chitosan and its derivatives have broad application prospects in the skin and soft tissue diseases, there is still a lack of review on this aspect.…”

Section: Introductionmentioning

confidence: 99%

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Xia

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Chitosan and its derivatives are bioactive molecules that have recently been used in various fields, especially in the medical field. The antibacterial, antitumor, and immunomodulatory properties of chitosan have been extensively studied. Chitosan can be used as a drug-delivery carrier in the form of hydrogels, sponges, microspheres, nanoparticles, and thin films to treat diseases, especially those of the skin and soft tissue such as injuries and lesions of the skin, muscles, blood vessels, and nerves. Chitosan can prevent and also treat soft tissue diseases by exerting diverse biological effects such as antibacterial, antitumor, antioxidant, and tissue regeneration effects. Owing to its antitumor properties, chitosan can be used as a targeted therapy to treat soft tissue tumors. Moreover, owing to its antibacterial and antioxidant properties, chitosan can be used in the prevention and treatment of soft tissue infections. Chitosan can stop the bleeding of open wounds by promoting platelet agglutination. It can also promote the regeneration of soft tissues such as the skin, muscles, and nerves. Drug-delivery carriers containing chitosan can be used as wound dressings to promote wound healing. This review summarizes the structure and biological characteristics of chitosan and its derivatives. The recent breakthroughs and future trends of chitosan and its derivatives in therapeutic effects and drug delivery functions including anti-infection, promotion of wound healing, tissue regeneration and anticancer on soft tissue diseases are elaborated.

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Section: Introductionmentioning

confidence: 99%

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Xia

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…The silica/chitosan sponges are characterized by promising water absorption properties and mechanical strength; these help achieve excellent hemostasis in the mouse tail amputation model. [14] Silica nanoparticles for loading tannic acid…”

Section: Silica Silica/chitosan Sponges Mouse Tail Amputation Modelmentioning

confidence: 99%

“…Several hemostatic materials can activate the hemostatic pathways in the human body in various ways. For example, chitosan sponges can promote hemostasis by activating and aggregating platelets exploiting the negative charges on the chitosan surface 14 . At the same time, the absorbent property of the sponge helps increase the local concentration of platelets and coagulation factors in the wound.…”

Section: Introductionmentioning

confidence: 99%

“…These also exhibited excellent antibacterial properties 38 . Silica- and chitosan-based composite sponges were used to study a rat tail break model, and these materials exhibited excellent hemostatic properties 14 . The positive charge on the chitosan surface and the negative charge of the diatom attracts each other, reducing the amount of powder residue on the trauma surface.…”

Section: Introductionmentioning

confidence: 99%

“…Alkylated chitosan promotes blood clotting when inserted into blood cell membranes 59 . A composite sponge characterized by a porous structure can be formed by lyophilizing a mixture of alkylated chitosan and silica 14 . The introduction of different amounts of alkyl groups on the chitosan surface and the different concentrations of alkylated chitosan affect the porosity of the sponge samples.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in the medical applications of hemostatic materials

Yu¹,

Wang²,

Liu³

et al. 2023

Theranostics

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Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials. Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials.

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Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control

Zhao

et al. 2022

Advanced Science

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Uncontrolled hemorrhage is a major cause of potentially preventable death in civilian trauma nowadays. Considerable concern has been given to the development of efficient hemostats with high blood absorption, self‐propelled property, and Ca2+ release ability, for irregularly shaped and noncompressible hemorrhage. Herein, Janus self‐propelled chitosan‐based hydrogel with CaCO3 (J‐CMH@CaCO3) is developed by partial ionic crosslinking of carboxylated chitosan (CCS) and Ca2+, gravity settlement, and photopolymerization, followed by removing the shell of CCS. The obtained J‐CMH@CaCO3 is further used as a hemostat powered by the internal CaCO3 and coordinated protonated tranexamic acid (J‐CMH@CaCO3/T). Bubbles are generated and detached to provide the driving force, accompanied by the release of Ca2+. The two aspects work in synergy to accelerate clot formation, endowing the J‐CMH@CaCO3/T with excellent hemostatic efficiency. The J‐CMH@CaCO3/T presents high blood absorption, favorable blood‐clotting ability, desired erythrocyte and platelet aggregation, and acceptable hemocompatibility and cytocompatibility. In rodent and rabbit bleeding models, the J‐CMH@CaCO3/T exhibits the most effective hemostasis to the best knowledge of the authors, wherein the hemorrhage is rapidly halted within 39 s. It is believed that the J‐CMH@CaCO3/T with self‐propelled property opens up a new avenue to design high‐performance hemostats for clinical application.

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A composite sponge based on alkylated chitosan and diatom-biosilica for rapid hemostasis

Cited by 40 publications

References 43 publications

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Recent advances in the medical applications of hemostatic materials

Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control

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