“…However, clinical data used in the mathematical models are hypothetical 8,10 and may deviate from data of actual clinical settings. Moreover, because EHR are used in the healthcare systems of specific regions, the generalizability of studies using EHR 11,15,16 is hindered by differing clinical practices, local populations, and demographics of individuals in the insurance systems. In this study, we performed a cost analysis using data from the J-CAP 14 study (a nationwide observational study reflecting recent trends in Japan) and the PRIAS-JAPAN study (a prospective observational study of the Japanese AS cohort).…”