A Comprehensive Analysis of Selenium-Binding Proteins in the Brain Using Its Reactive Metabolite

Yoshida, Sakura; Hori, Eriko; Ura, Sakiko; Haratake, Mamoru; Fuchigami, Takeshi; Nakayama, Morio

doi:10.1248/cpb.c15-00689

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…Yoshida et al [29] reported a comprehensive method for identifying the selenium-binding proteins using PenSSeSPen as a model of the selenium metabolite, selenotrisulfide (RSSeSR, STS), which was applied to a complex cell lysate generated from the rat brain. The authors stated that a thiol-containing protein at m/z 15155 in the brain cell lysate was identified as the cystatin-12 precursor (CST12) from a rat protein database search and a tryptic fragmentation experiment.…”

Section: Brain Antioxidant Homeostasy In Relation To Selenium and Gshpxmentioning

confidence: 99%

“…CST12 belongs to the cysteine proteinase inhibitors of the cystatin superfamily that are of interest in mechanisms regulating the protein turnover and polypeptide production in the central nervous system and other tissues. Consequently, CST12 is suggested to be one of the cytosolic proteins responsible for the selenium metabolism in the brain [29].…”

Section: Brain Antioxidant Homeostasy In Relation To Selenium and Gshpxmentioning

confidence: 99%

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Reactive Oxygen Species and Selenium in Epilepsy and in Other Neurological Disorders

Antila¹,

Westermarck²,

Latvus³

et al. 2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

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Oxidative stress has been implicated in epilepsy and various neurodegenerative disorders. In this review, we elaborate oxidative stress-mediated neuronal loss and assess the role of selenium in some neurological disorders including epilepsy. Selenium as an essential trace element has attracted the attention of many researchers because of its potentialities in human health. It has an important role in the brain, immune response, defense against tissue damage, and thyroid function. Selenium forms part of the active site of the peroxide-destroying enzyme glutathione peroxidase (GSHPx), and it also has other functions, for example in biotransformation and detoxification. Functional and clinical consequences of selenium deficiency states in neurological diseases have been described, and the selenium requirement, which is influenced by various processes, has been discussed. Wide variations have been found in selenium status in different parts of the world, and populations or groups of patients exposed to marginal deficiency are more numerous than was previously thought. Chronic diseases, such as neurological disorders, heart disease, diabetes, cancer, aging, and others, are reported to associate with markers of oxidative damage. It is, therefore, not unreasonable to suggest that antioxidants would alleviate the oxidative damage, resulting in health improvements. In recent years, accumulated evidence in nutrigenomics, laboratory experiments, clinical trials, and epidemiological data have established the role of selenium in a number of conditions. Most of these effects are related to the function of selenium in the antioxidant enzyme systems. Current research activities in the field of human medicine and nutrition are devoted to the possibilities of using selenium as an adjuvant for the treatment of degenerative or free radical diseases such as neurological disorders, inflammatory diseases, and cancer.

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Section: Brain Antioxidant Homeostasy In Relation To Selenium and Gshpxmentioning

confidence: 99%

Section: Brain Antioxidant Homeostasy In Relation To Selenium and Gshpxmentioning

confidence: 99%

Reactive Oxygen Species and Selenium in Epilepsy and in Other Neurological Disorders

Antila¹,

Westermarck²,

Latvus³

et al. 2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

View full text Add to dashboard Cite

show abstract

“…According to previously reported procedures [14,15], X-ray photoelectron spectroscopy (XPS) was performed using an AXIS-ULTRA instrument fitted with a delay-line detector and a monochromated Al Kα line (0.8339 nm, 1.486 keV) operating at 10 kV and 13 mA (Shimadzu Corp., Kyoto, Japan).…”

Section: X-ray Photoelectron Spectroscopymentioning

confidence: 99%

Selenoprotein L-inspired nano-vesicular peroxidase mimics based on amphiphilic diselenides

Uehara

Yoshida

Emaya

et al. 2018

Colloids and Surfaces B: Biointerfaces

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In this study, we developed selenoprotein L-inspired nano-vesicular peroxidase mimics based on amphiphilic diselenides. Selenocystine (SeCyst) was used as the starting material for the synthesis of four liposomal membrane-compatible diselenide derivatives (R-Se-Se-R') with two hydrophobic tails and a polar part. The diselenide derivatives were successfully incorporated into the phosphatidylcholine (PC)-based nano-vesicular scaffold. The results of the particle diameter and zeta-potential measurements suggested that the functional diselenide moiety was placed around the outer surface, not in the hydrophobic interior, of the liposomal membrane structures. The GPx-like catalytic activity of the diselenide/PC liposomes was determined by the conventional NADPH method using glutathione as the reducing substrate. For three peroxide substrates, i.e., hydrogen peroxide, organic tert-butyl hydroperoxide and cummen hydroperoxide, the cationic property-possessing diselenide derivatives in the PC-based liposomes resulted in a higher catalytic activity in comparison to electrically neutral and anionic derivatives. Overall, the diselenide derivatives at the surface of a liposomal colloidal scaffold could exert a GPx-like catalytic activity in physiological aqueous media.

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“…The main selenoproteins in blood are selenoproteins P which contribute approximately 50% of the total plasmatic selenium and glutathione peroxidase which count 10-30% of selenium in plasma [ 4 ]. In the brain, selenium concentration is reported to be far less variable than those in the peripheral tissues and organs [ 5 ]. This fact implied the importance of selenium for maintaining the integrity of brain functions and the distinctive selenium metabolism and the regulatory mechanism in the brain [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the brain, selenium concentration is reported to be far less variable than those in the peripheral tissues and organs [ 5 ]. This fact implied the importance of selenium for maintaining the integrity of brain functions and the distinctive selenium metabolism and the regulatory mechanism in the brain [ 5 ]. Otherwise, studying the relationship between selenium and progression of patients suffering from brain disorder such as traumatic brain injury (TBI) may be useful.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of selenium and C - reactive protein in comatose patients with severe traumatic brain injury during the first week of hospitalization: case-control study

Belatar¹,

Laidi²,

Abidi³

et al. 2018

Pan Afr Med J

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IntroductionMortality and morbidity related to traumatic brain injuries still remain high in patients. Many authors reported the importance of Selenium in maintaining the integrity of brain functions. This fact is supported by clinical evidence that therapy with selenium supplementation could help patients suffering from brain disorders like neurodegenerative diseases. The aim of our study was to assess the relationship between Selenium concentration in serum and evolution of comatose patients with severe traumatic brain injury, in the first week of admission, and the correlation between selenium and C-reactive protein.MethodsThis case-control study was conducted with 64 comatose patients with TBI, in the Department of Anesthesiology and Reanimation, IbnSina University Hospital and Hospital of specialties in Rabat-Morocco, and healthy volunteers recruited in Blood transfusion center of Rabat. Blood sampling was collected from TBI patients, in the first week (3h after admission and each 48h during one week), and from healthy volunteers one time. Concentration of Se in serum was determined by electrochemical atomic absorption spectrometry. Statistical analysis was performed using Statistical software (SPSS) and the cases and controls were compared using the Mann-Whitney U test. A P-value < 0.05 was considered to be statistically significant.ResultsComparison selenium concentration in the first day (D0), third day (D2) and fifth day according to the death and survival statue in patients did not show statistical significance (p > 0.05). Selenium concentration of D0 in patients and Selenium concentration in control group also did not show statistical significance (p > 0.05). Similarly, we did not report a correlation between selenium and C-reactive protein.ConclusionAccording to our data selenium and CRP may not play a role in progression of coma state in patients with severe traumatic brain injury.

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A Comprehensive Analysis of Selenium-Binding Proteins in the Brain Using Its Reactive Metabolite

Cited by 7 publications

References 42 publications

Reactive Oxygen Species and Selenium in Epilepsy and in Other Neurological Disorders

Reactive Oxygen Species and Selenium in Epilepsy and in Other Neurological Disorders

Selenoprotein L-inspired nano-vesicular peroxidase mimics based on amphiphilic diselenides

Serum levels of selenium and C - reactive protein in comatose patients with severe traumatic brain injury during the first week of hospitalization: case-control study

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