A Comprehensive Analysis of the PI3K/AKT Pathway: Unveiling Key Proteins and Therapeutic Targets for Cancer Treatment

Fadhal, Emad

doi:10.1177/11769351231194273

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…We suggested that proteins in the central position, particularly those engaged in sensory functions, could be potential targets for therapeutic intervention. Furthermore, we identified proteins near the network center as potential targets for therapeutic intervention [15][16][17]. Based on previous analyses, our current investigation focused on zone two, abundant in proteins linked to diverse cellular processes.…”

Section: Resultsmentioning

confidence: 99%

“…As a result, we deduced that assessing PPIs within a metric space, particularly considering zones relative to the center, can unveil pivotal distinctions between PPI networks observed in healthy and pathological tissues. Following the methodology outlined in our prior research, our continuing investigation proposes that core zones within specific human protein interaction networks exhibit a noteworthy enrichment of essential proteins and recognized drug targets [14][15][16][17].…”

Section: Methodsmentioning

confidence: 99%

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The Significance of Key Proteins in the RAS Signaling Pathway: Implications for Cancer and Therapeutic Targets

Fadhal

2024

OBM Genet

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The RAS signaling pathway is a crucial cell transduction pathway central to transmitting signals from outside the cell to the cell nucleus and influencing fundamental biological mechanisms like cell growth, division, and specialization. This signaling pathway has recently received much attention in scientific research because of its involvement in various diseases, especially carcinogenesis. Our study identified the significance of crucial proteins in the RAS signaling cascade in cancer development and progression. We found that proteins such as PDGFRB, PDGFB, IGF1, HRAS, HGF, FGF10, and ABL1 are involved in various types of cancer and could serve as potential therapeutic targets. Misregulation of these proteins may result in unregulated cell proliferation and contribute to cancer development and maintenance. The study also emphasizes the importance of oncogenes in cancer development, with RAS being identified as a pivotal oncogene. In addition, the findings indicate several proteins, including PDGFRA, NRAS, HRAS, CSF1R, KIT, MET, ABL1, FGFR2, FGFR3, and KRAS, function as oncogenes and are related to different forms of cancer and diseases. Targeted therapies for these proteins are being investigated in various cancer types, including gastrointestinal stromal tumors, chronic myelogenous leukemia, and bladder cancer. Moreover, we identified NF1 as a critical tumor suppressor gene essential in regulating cellular proliferation. Mutations in the NF1 gene lead to neurofibromatosis category 1. This paper emphasizes the significance of crucial proteins implicated in the RAS signaling pathway in cancer growth and advancement. Understanding the complexity of these proteins and their dysregulation could offer essential insights into the progression of practical treatment approaches that enhance and refine cancer therapies. These findings provide promising avenues for further research and advances in cancer treatment and give us hope for better outcomes in the fight against this challenging disease.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Significance of Key Proteins in the RAS Signaling Pathway: Implications for Cancer and Therapeutic Targets

Fadhal

2024

OBM Genet

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“…Furthermore, we found that suppressor proteins such as EP300, TP53, CASP8, PIK3R1, CREBBP, and PTCH1 are of interest in gene regulation, DNA repair, apoptosis, and cell signaling [20]. Recent studies have shown that key zone 2 proteins such as KIT, ERBB2, PDGFRA, MET, FGFR2, and FGFR3 are involved in numerous cancer-associated signaling pathways, particularly the PI3K/AKT pathway [21].…”

Section: Resultsmentioning

confidence: 99%

Unveiling Crucial Proteins in Zone 2 of the Human Protein Interaction Network: Implications for Cancer Research and Therapeutic Targeting

Fadhal

2023

TOBIOIJ

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Background: Protein-protein interaction networks are of great importance for understanding the complexity of biological processes and diseases, including cancer. However, detecting key proteins that regulate and mediate biological processes within these networks can be challenging due to their enormous size and complexity. Identification of these important proteins is of great importance for identifying therapeutic targets and elucidating molecular mechanisms in various types of cancer. Aims: The aim of this study was to investigate the importance of zone 2, the central zone of the protein interaction network in humans, and to identify potential therapeutic targets for common proteins expressed in different types of cancer. Method: We analyze zone 2 of the human protein interaction network and identify proteins within the network that function as key regulators or mediators of biological processes. We use multiple biological databases to collect data on protein-protein interactions and cancer types. We analyze the data to obtain promising proteins for different types of cancer. Results: Our analysis identified several important proteins in several types of cancer. These proteins play important roles in regulating biological processes within the network. Conclusion: Our approach effectively identifies essential proteins within protein-protein interaction networks across multiple cancer types. Furthermore, the identification of key proteins in zone 2 of the human protein interaction network will provide new insights into the molecular mechanisms underlying various cancer types and pave the way for new therapeutic targets.

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“…Additionally, PPI networks have proven instrumental in discovering novel biomarkers for early diagnosis and improved patient prognosis [12] [24]. Furthermore, it is vital to identify crucial proteins through PPI analysis to gain a comprehensive understanding of cellular processes, disease mechanisms, and potential targets for therapeutic [7]. Current approaches often lack a unified framework, hindering their full potential.…”

Section: Introductionmentioning

confidence: 99%

Exploring Lung Cancer Protein Network: Understanding Structure and Function through Metric Space Modeling

Fadhal

2024

Eur. J. Pure Appl. Math.

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Lung cancer remains a significant health threat with high mortality rates. Using graph theory, we modeled the protein-protein interaction (PPI) network in lung cancer to explore its complex structure. This approach allows for the analysis of network properties and the identification of key proteins driving biological processes. Our analysis revealed RPS27A as a central proteinwithin the network, associated with diverse functions related to ribosome biogenesis, translation, cell growth, apoptosis, and cancer progression. This suggests that RPS27A may have multiple functions in cancer development and progression, including in MAPK signaling pathways. Importantly, our study uniquely identifies RPS27A as a central hub in lung cancer PPI networks, shedding light on its pivotal role in disease pathogenesis. Additionally, we identified a central network zone enriched with proteins involved in key signaling pathways, presenting novel insights into potential therapeutic targets for lung cancer treatment. Pathway enrichment analysis further highlighted functional specialization across network zones, providing a comprehensive understanding of the intricate interplay between biological pathways in lung cancer progression. This study underscores the multifaceted roles of central proteins like RPS27A within lung cancer’s PPI network and the network’s potential for pinpointing therapeutic targets, presenting a novel perspective on the intricate network of molecular interactions driving lung cancer pathogenesis.

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A Comprehensive Analysis of the PI3K/AKT Pathway: Unveiling Key Proteins and Therapeutic Targets for Cancer Treatment

Cited by 8 publications

References 39 publications

The Significance of Key Proteins in the RAS Signaling Pathway: Implications for Cancer and Therapeutic Targets

The Significance of Key Proteins in the RAS Signaling Pathway: Implications for Cancer and Therapeutic Targets

Unveiling Crucial Proteins in Zone 2 of the Human Protein Interaction Network: Implications for Cancer Research and Therapeutic Targeting

Exploring Lung Cancer Protein Network: Understanding Structure and Function through Metric Space Modeling

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