2022
DOI: 10.1111/eci.13860
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A comprehensive and longitudinal cardiac magnetic resonance imaging study of the impact of coronary ischemia duration on myocardial damage in a highly translatable animal model

Abstract: Objectives We performed a comprehensive assessment of the effect of myocardial ischemia duration on cardiac structural and functional parameters by serial cardiac magnetic resonance (CMR) and characterized the evolving scar. Background CMR follow‐up on the cardiac impact of time of ischemia in a closed‐chest animal model of myocardial infarction with human resemblance is missing. Methods Pigs underwent MI induction by occlusion of the left anterior descending (LAD) coronary artery for 30, 60, 90 or 120 min and… Show more

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Cited by 4 publications
(3 citation statements)
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“…The type, extent, and pattern of spatial distribution and the temporal sequence of ischemia–reperfusion in pigs resemble the human clinical situation more closely than many other animal models [ 19 , 33 ]. Moreover, utilizing pigs allows researchers to employ the same techniques, such as cardiac catheterization or magnetic resonance imaging, and derived key parameters as in examinations of the human heart [ 57 , 64 ].…”
Section: Introductionmentioning
confidence: 99%
“…The type, extent, and pattern of spatial distribution and the temporal sequence of ischemia–reperfusion in pigs resemble the human clinical situation more closely than many other animal models [ 19 , 33 ]. Moreover, utilizing pigs allows researchers to employ the same techniques, such as cardiac catheterization or magnetic resonance imaging, and derived key parameters as in examinations of the human heart [ 57 , 64 ].…”
Section: Introductionmentioning
confidence: 99%
“…A properly selected animal model will make it possible to install the implant being tested with great success, avoid fatal complications and death of experimental animals due to the discrepancy in the size of the structures in their hearts, blood vessels and medical devices. The most advantageous method to accurately measure the size of the heart and its structures is undoubtedly multispiral computed tomography [9,10]. However, in daily experimental practice, preference should be given to the simplest and fastest method to evaluate the anatomy of the target zone.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, it will help researchers to avoid fatal complications and deaths of experimental animals caused by the mismatch in the sizes of the anatomical structures and medical devices. Multispiral computed tomography is considered to be the most advantageous method for making accurate measurements of the heart and its structures [ 9 , 10 ]. However, in daily experimental practice, it is preferable to use the simplest and quickest method to evaluate the anatomy of the target area.…”
Section: Introductionmentioning
confidence: 99%