Background Dementia care requires inter-disciplinary collaboration starting from formal health professional education. Yet, little is known about how undergraduate medical and nursing students perceive dementia care in China. The aim of this study was to investigate undergraduate medical and nursing students’ knowledge, attitudes and care approach of dementia in China. Methods A cross-sectional survey was conducted. Students enrolled in a 5-year Bachelor of Medicine Program and a 4-year Bachelor of Nursing Program from four universities with campuses across Eastern, Western, Southern and Northern China were recruited into the study. Three validated instruments, Alzheimer’s Disease Knowledge Scale (AKDS), Dementia Care Attitude Scale (DCAS) and Approach to Advanced Dementia Care Questionnaire (ADCQ), were used to measure students’ dementia knowledge, attitudes and perceived care approach. Data were collected using a self-administered survey. Results The number of medical and nursing students completing the survey was 526 and 467 respectively. The overall mean score of students’ dementia knowledge measured by the ADKS was 19.49 (SD=2.82) out of 30, students’ attitudes to dementia was 29.92(SD=3.35) out of 40, and students’ person-centred care approach of dementia was 5.42 (SD=2.20) out of 13. Students’ overall knowledge towards dementia was poor and the attitudes were generally positive. Medical students demonstrated higher dementia knowledge scores and showed less positive attitude scores than nursing students (p<0.05). Students would not apply a person-centered care approach. There were no statistically significant differences in the mean scores of ADCQ between nursing students and medical students. Conclusions Study results highlight the urgent need to implement an inter-disciplinary approach to increasing dementia education among Chinese medical and nursing students, and ensuring that students have adequate knowledge, attitudes and experience in the care of people with dementia.