A comprehensive assessment of environmental exposures and the medical history guides multidisciplinary discussion in interstitial lung disease

Dodia, N.; Amariei, D.; Kenaa, Blaine; Corwin, Doug; Chelala, Lydia; Britt, E. James; Sachdeva, Ashutosh; Luzina, Irina G.; Hasday, Jeffrey D.; Shah, Nirav G.; Atamas, Sergei P.; Franks, Teri J.; Burke, Allen; Hines, Stella E.; Galvin, Jeffrey R.; Todd, Nevins W.

doi:10.1016/j.rmed.2021.106333

Cited by 10 publications

(2 citation statements)

References 40 publications

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“…Inflammaging [130] Chronic inflammation in the airways Therapeutic intervention including SIRT1 activators or polyphenols [131] Comorbidities and multimorbidity [132,133] Multiple comorbid conditions, such as cardiovascular diseases and diabetes Care coordination [134,135] Exposure history [136] Lifetime of exposure to environmental pollutants, occupational hazards, and cigarette smoke Lifestyle intervention, awareness [137]…”

Section: Pathophysiology Consequences Managementmentioning

confidence: 99%

Pulmonary Diseases in Older Patients: Understanding and Addressing the Challenges

Joshi

2024

Geriatrics

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As the global population ages, pulmonary diseases among older people have emerged as a significant and growing public health concern. The increasing incidence of these conditions has led to higher rates of morbidity and mortality among older adults. This perspective study offers a thorough overview of the prevalent pulmonary diseases affecting the elderly demographic. It delves into the challenges encountered during the diagnosis and management of these conditions in older individuals, considering factors such as comorbidities, functional limitations, and medication complexities. Furthermore, innovative strategies and personalized interventions such as precision medicine, advanced therapies, telemedicine solutions, and patient-centered support systems aimed at enhancing the care provided to older individuals grappling with pulmonary disorders are thoroughly explored. By addressing the unique needs and complexities of this vulnerable population, healthcare systems can strive towards improving outcomes and enhancing the quality of life for elderly individuals affected by pulmonary diseases.

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Section: Pathophysiology Consequences Managementmentioning

confidence: 99%

Pulmonary Diseases in Older Patients: Understanding and Addressing the Challenges

Joshi

2024

Geriatrics

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“…Multidisciplinary discussion (MDD) can facilitate a timely and accurate diagnosis of ILD, incorporating input from various clinicians, radiologists, pathologists and other specialists. Although the 2022 ATS/ERS/JRS/ALAT guidelines (1) focus on MDD for IPF, there is recognition of the importance of MDD for other ILDs as well(25, 26,35, 36). While the current study found that in just over 75% of cases no additional physicians were involved in the diagnosis, 83% of respondents reported being part of a multidisciplinary team, with most having a role in diagnosis and ongoing management.…”

mentioning

confidence: 99%

Treatment patterns and patient journey in progressive pulmonary fibrosis: a cross-sectional survey

Chaudhuri,

Spagnolo,

Valenzuela

et al. 2024

Preprint

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Background For patients with interstitial lung diseases (ILD) with a progressive pulmonary fibrosis (PPF) phenotype, current knowledge of disease characteristics at diagnosis, patient journey, and treatment is limited. This study aimed to describe demographics and clinical experiences of patients presenting with PPF in a European real-world setting. Methods Data were analysed from the Adelphi Real World PPF-ILD Disease Specific Programme™, a cross-sectional survey of pulmonologists and rheumatologists in five European countries (France, Germany, Italy, Spain, United Kingdom) and internal medicine specialists (France) from April to October 2022. Physicians provided data for up to 12 consecutive patients with physician-confirmed ILD with a progressive phenotype other than idiopathic pulmonary fibrosis. Analyses were descriptive. Results Overall, 265 physicians reported on 1,335 patients. Mean (standard deviation [SD]) age at survey date was 60.4 (11.6) years, 91.2% were white, 58.1% female, 44.0% non-smokers. The mean age (SD) at first healthcare professional (HCP) visit was 57.6 (12.1) years, with 63.3% patients first consulting a primary care physician. There was a mean delay of 7.8 (22.7) months between first ILD symptom and HCP visit, and another 7.7 (12.8) months to ILD diagnosis. There were 47.7% patients with physician-reported moderate ILD at survey date, 42.3% with mild and 10.0% with severe ILD. Disease progression was reported in the 12 months prior to the survey for 19.5% of patients; of these, progression was based on worsening symptom severity in 27.3% and on lung function decline in 25.8%. For patients experiencing symptoms prior to ILD diagnosis (72.8%), the most common symptoms were dyspnoea on exertion (80.5%) and cough (57.8%). Overall, 17.4% of patients were misdiagnosed prior to ILD diagnosis, with chronic obstructive pulmonary disease suspected in 39.2% of them. The most frequent comorbidities were anxiety (16.9%) and gastroesophageal reflux (15.5%). Although 77.8% of patients were receiving treatment for ILD at survey date, 15.6% of patients had never been prescribed treatment for ILD. Conclusions This real-world study expands our understanding of patients, diagnostic delays and treatment gaps experienced by patients diagnosed with PPF in Europe. Given the progressive nature of PPF, diagnostic delay may lead to poor outcomes, including shorter survival. Trial registration: n/a

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Interstitial Lung Disease: A Focused Review for the Emergency Clinician

Constantino¹,

Gottlieb²,

Long³

2023

The Journal of Emergency Medicine

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A comprehensive assessment of environmental exposures and the medical history guides multidisciplinary discussion in interstitial lung disease

Cited by 10 publications

References 40 publications

Pulmonary Diseases in Older Patients: Understanding and Addressing the Challenges

Pulmonary Diseases in Older Patients: Understanding and Addressing the Challenges

Treatment patterns and patient journey in progressive pulmonary fibrosis: a cross-sectional survey

Interstitial Lung Disease: A Focused Review for the Emergency Clinician

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