A Comprehensive Consolidation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Bronchopulmonary Dysplasia

Bahrami, Reza; Golshan-Tafti, Mohammad; Dastgheib, Seyed Alireza; Alijanpour, Kamran; Yeganegi, Maryam; Lookzadeh, Mohamad Hosein; Mirjalili, Seyed Reza; Azizi, Sepideh; Aghasipour, Maryam; Shiri, Amirmasoud; Noorishadkam, Mahmood; Neamatzadeh, Hossein

doi:10.1080/15513815.2024.2400145

Fetal and Pediatric Pathology

2024

DOI: 10.1080/15513815.2024.2400145

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A Comprehensive Consolidation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Bronchopulmonary Dysplasia

Reza Bahrami,

Mohammad Golshan-Tafti,

Seyed Alireza Dastgheib

et al.

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Cited by 2 publications

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The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review

Golshan-Tafti,

Bahrami,

Dastgheib

et al. 2024

Front. Pediatr.

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ObjectivePrevious studies on the link between VEGF gene polymorphisms and bronchopulmonary dysplasia (BPD) have yielded inconsistent results. This meta-analysis sought to clarify the relationship between genetic variations in the VEGF gene and the risk of BPD.MethodsData were collected from multiple databases, including PubMed, Scopus, EMBASE, and CNKI, up to January 5, 2024.ResultsNineteen case-control studies were analyzed, featuring 1,051 BPD cases and 1,726 healthy neonates. The analysis included four studies on the −460T/C polymorphism (312 cases, 536 controls), four on the −2578C/A polymorphism (155 cases, 279 controls), six on the +405G/C polymorphism (329 cases, 385 controls), and five on the +936C/T polymorphism (225 cases, 526 controls). The meta-analysis suggests that the −460T/C polymorphism may protect against BPD (C vs. T: OR = 0.715, 95% CI 0.543–0.941, p = 0.017; CC vs. TT: OR = 0.478, 95% CI 0.233–0.983, p = 0.045; CC vs. CT + TT: OR = 0.435, 95% CI 0.248–0.764, p = 0.004). No significant associations were found between the −2578C/A, +405G/C, and +936C/T polymorphisms and BPD susceptibility.ConclusionsThis meta-analysis indicates that the C allele of the −460T/C polymorphism may offer protection against BPD. No significant associations were observed for the −2578C/A, +405G/C, and +936C/T polymorphisms.

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The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review

Golshan-Tafti,

Bahrami,

Dastgheib

et al. 2024

Front. Pediatr.

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Association of TNF-α genetic variants with neonatal bronchopulmonary dysplasia: consolidated results

Shams,

Dastgheib,

Mousavi-Beni

et al. 2024

Front. Pediatr.

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ObjectivesInflammation is increasingly recognized as a key factor in the pathophysiology of bronchopulmonary dysplasia (BPD). While previous research has established significant links between TNF-α polymorphisms and BPD susceptibility, further validation of these associations is needed. This study aims to examine the relationship between TNF-α polymorphisms and the risk of BPD.MethodsAll relevant articles published before October 1, 2024, have been screened in the PubMed, Web of Science, CNKI, and Scopus databases.ResultsA total of 14 case-control studies were conducted: five studies with 1,252 cases and 1,377 controls on −308G/A, three studies with 1,180 cases and 1,194 controls on −238G/A, four studies with 149 cases and 192 controls on −857C/T, and two studies with 82 cases and 162 controls on 1,031 T/C. A significant association was found between the TNF-α −238G/A polymorphism and the risk of BPD. However, no significant relationships were observed for the TNF-α −308G/A, −857C/T, and 1,031 T/C polymorphisms regarding BPD susceptibility.ConclusionsOur findings indicate a significant association between the TNF-α −238G/A polymorphism and the susceptibility to BPD in preterm neonates, suggesting potential biomarkers for its pathogenesis. However, this meta-analysis has limitations, including possible publication bias and heterogeneity due to the limited number of studies, which may affect the reliability of our conclusions. Moreover, population variability further complicates the interpretation of the link between TNF-α polymorphisms and BPD risk.

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A Comprehensive Consolidation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Bronchopulmonary Dysplasia

Cited by 2 publications

References 48 publications

The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review

The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review

Association of TNF-α genetic variants with neonatal bronchopulmonary dysplasia: consolidated results

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