A Comprehensive Drug Review on <i>Cuntai Varral Cūranam</i> for its Anti-diabetic Potential on <i>Matumēkam</i> (Type II Diabetes Mellitus)

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disorder caused by inadequate insulin production by the pancreas or insufficient insulin utilisation by the body. WHO (World Health Organisation) estimates that Non-Communicable Diseases (NCDs) account for 75% of all worldwide fatalities and 2 million death per year account due to diabetes including kidney disease. The prevalence of DM is comparatively higher in lower and middle-income countries than in high-income countries. The IDF states that approximately 10.5% of adults aged 20 to 79 have diabetes, and half of them are unaware of their condition It is estimated that by 2045, the number of adults living with diabetes will rise to 46%. Diabetes Mellitus can be clinically correlated with signs and symptoms of Inippu nīr (NSMC-XGB 1.4) and Matumēkam and its complications stated as in Avattaikal in Siddha text. Traditional plant remedies for diabetes have been considered excellent oral therapeutic options due to their effectiveness, safety and less adverse effects. Cuntai Varral Cūranam (CVC) is the polyherbal formulation prescribed as a single or supplemental drug for gastrointestinal disorders and used in the management of DM and its ailments in practice. This study aims to review the Anti-diabetic efficacy of CVC through its phytochemical, pharmacological aspects, and basic Siddha principle (Mukkurram, cuvai, vīriyam and vipākam) for the ingredients of CVC. The pharmacological actions like anti-diabetic, hypolipidemic, hepatoprotective, nephroprotective, cardioprotective, antioxidant, and anti-microbial activities and the enzyme inhibition pathways of the ingredients were analysed. The result suggested that CVC might be an effective anti-diabetic drug in the management of DM and its complications due to its synergistic effect.