A comprehensive enhanced depth imaging spectral-domain optical coherence tomography analysis of pseudoexfoliation spectrum from non-glaucomatous to advanced stage glaucoma in the aspect of Bruch's membrane opening-minimum rim width

Hepokur, Mustafa; Elgin, Cansu Yüksel; Gunes, Medine; Sali, Fatma; Oğuz, Halit

doi:10.1007/s10792-021-02181-6

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…Althoughe Li et al 32 found a significant decrease in central sub-macular CT in the group with PEXG compared with the control group, they reported a significant decrease only in the nasal inferior quadrant in peripapillary CT. Unlike these findings, Hepokur et al 33 reported there was no significant difference in peripapillary and sub-foveal CT between patients with early stage PEXG and patients with advanced PEXG. Ozge et al 12 reported, however, that there was no significant difference between the sub-foveal and peripapillary CT of the PEXG, PEXS, and control groups.…”

Section: Discussionmentioning

confidence: 79%

Optic Nerve Head, Peripapillary and Macular Microvascular Characteristics in Patients With Unilateral Pseudoexfoliation Glaucoma

Balci

Çakır

Altan

2023

Journal of Glaucoma

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Précis: In unilateral pseudoexfoliation glaucoma (PEXG), there may be decreased choroidal vascularity index (CVI), radial peripapillary capillary plexus’ perfusion and flow. CVI may also be reduced in fellow eyes, suggesting that PEXG is bilateral disease. Purpose: Evaluation of peripapillary and macular choroidal microvascularity and radial peripapillary capillary plexus (RPC) in both eyes with unilateral pseudoexfoliation glaucoma (PEXG) and healthy eyes. Materials and Methods: Ninety-six eyes of 48 patients with unilateral PEXG (PEX (+): 48 eyes with PEXG; PEX (−): 48 eyes without PEX) and the right eyes of 45 age- and sex-matched healthy controls were included in the study. Choroidal vascular index (CVI) was calculated on enhanced depth imaging optical coherence tomography (EDI-OCT) scans. RPC vascular layer were evaluated by OCT-Angiography (OCTA). Results: Macular CVI (mCVI), temporal and nasal peripapillary CVI (pCVI) was significantly decreased in the PEX (+) compared to the PEX (−) and control group (P<0.05 for all). While there was a significant difference between PEX (−) and the control group in terms of mCVI and temporal pCVI, there was no significant difference between the two groups in terms of nasal pCVI (P=0.008, P=0.036 and P=0.604, respectively). There was a significant difference in perfusion density (PD) and flux index (FI) between PEX (+) group, PEX (−) group and control group in all quadrants and average value (P<0.05 for all). Although the PD and FI values in all quadrants and average values of the PEX (−) group were lower than the control group, this difference was not significant. Conclusions: CVI in the macula and peripapillary region tends to decrease in eyes with PEXG. Similarly, PD and FI were lower in eyes with PEXG. Low mCVI and temporal pCVI can also be seen in eyes without PEX.

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Section: Discussionmentioning

confidence: 79%

Optic Nerve Head, Peripapillary and Macular Microvascular Characteristics in Patients With Unilateral Pseudoexfoliation Glaucoma

Balci

Çakır

Altan

2023

Journal of Glaucoma

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Evaluation of the Inner Macula Layers, Circumpapillary Retinal Nerve Fiber Layer, and Minimum Rim Width Thickness in Patients With Pseudoexfoliation Syndrome Without Glaucoma Compared With Controls

Azimi,

Bostanian,

Jalalpour

et al. 2024

Journal of Glaucoma

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Precis: Minimum Rim width (MRW) is thinner in patients with non-glaucomatous pseudoexfoliation syndrome (XFS) and may be the first parameter affected in these patients due to the vascular nature of this disease. Purpose: To evaluate the macular inner layers, circumpapillary retinal nerve fiber layer (cp-RNFL), and MRW in non-glaucomatous XFS compared to healthy subjects. Methods: In this prospective study, using Heidelberg Spectralis optical coherence tomography (OCT) with glaucoma module premium edition, 8×8 grids of macular inner layers were exported, and the global, superior, and inferior thicknesses were used. Also, on the deviation map, the elliptical annulus around the fovea, which was 4.8×4 mm in size, was analyzed. Moreover, both groups calculated cp-RNFL and MRW values in three superior and three inferior sectors. Results: Thirty-two eyes of thirty-two subjects with clinically detected non-glaucomatous XFS and 30 right eyes of age-sex-matched healthy controls were included. No significant difference was found between the case and control groups concerning the intraocular pressure (IOP) (14.94±2.09 mmHg vs. 15.27±2.27, respectively, P value= 0.556). The MRW of the superotemporal segment (MRW-TS) was significantly thinner in the XFS group compared with the control ones (303.69±60.49 µm vs. 341.43±56.19 µm, P = 0.014). No significant differences were found in the other sectors of MRW, macular inner layers, and cp-RNFL thickness between the groups. Conclusion: These findings indicate that the MRW, especially in the superotemporal sector, may show early eye damage in patients with non-glaucomatous XFS, and it may be used to detect the early stage of glaucoma in XFS.

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Evaluation of macula with optical coherence tomography-angiography device in glaucomatous and disease-free individuals with unilateral pseudoexfoliation material.

YÜKSEL ELGİN

2023

Turkish Journal of Clinics and Laboratory

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Amaç: Tek taraflı pseudoekfolyasyon materyali (XFM) izlenen bireylerin; glokom geliştiği ve gelişmediği durumlarda makula vasküler yoğunluğunun gözler arası değişimini gözlemlemek. Gereç ve yöntemler: 38 sayıda tek taraflı pseudoeksfolyasyon sendromlu (XFS) bireyin 76 gözü ve 36 sayıda tek taraflı pseudoeksfolyasyon glokomlu (XFG) hastanın 72 gözü çalışmaya dahil edilmiştir. Her iki grubun XFM olan ve olmayan gözlerinin OCT-A ile incelenen tüm makuler belirteçleri standart ortalama karşılaştırmalı t testi ile değerlendirilmiştir. Her iki gruptaki XFM pozitif ve negatif olan göz grupları birbirleriyle ve gruplar arasında Kruskal-Wallis testi ile kıyaslanmıştır. Bulgular : Tek taraflı XFS olan hastaların gözler arası yüzeyel kapiller pleksus yoğunluğunda anlamlı farklılıklar minimal görülürken tek taraflı XFG’lerin gözler arası makulanın totalinde (p= 0,0004) üst ve alt yarımında (p=0.0018, p=0.0002), fovea (p=0,014), parafovea (p=0,0411) ,parafoveanın inferior yarımı (p=0,0126) ve temporalinde (p=0,0126); glokomlu gözlerde anlamlı düzeyde damar yoğunluğunda azalma dikkati çekmektedir. Derin kapiller pleksusta ise hem grup içi hem gruplar arası kıyaslamalarda anlamlılık, yüzeyel damar tabakasına göre azalmıştır. Sonuç: Medikal tedaviyle kontrol edilen glokom tablolarında makula bölgesindeki özellikle yüzeyel kapiller pleksusun yoğunluğunda azalma olduğu gösterilmiştir. Ancak bu damarsal azalma glokomsuz gözlerde XFM varlığında öncü bulgu olarak gösterilememiştir.

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A comprehensive enhanced depth imaging spectral-domain optical coherence tomography analysis of pseudoexfoliation spectrum from non-glaucomatous to advanced stage glaucoma in the aspect of Bruch's membrane opening-minimum rim width

Cited by 3 publications

References 59 publications

Optic Nerve Head, Peripapillary and Macular Microvascular Characteristics in Patients With Unilateral Pseudoexfoliation Glaucoma

Optic Nerve Head, Peripapillary and Macular Microvascular Characteristics in Patients With Unilateral Pseudoexfoliation Glaucoma

Evaluation of the Inner Macula Layers, Circumpapillary Retinal Nerve Fiber Layer, and Minimum Rim Width Thickness in Patients With Pseudoexfoliation Syndrome Without Glaucoma Compared With Controls

Evaluation of macula with optical coherence tomography-angiography device in glaucomatous and disease-free individuals with unilateral pseudoexfoliation material.

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