2011
DOI: 10.1016/j.molcel.2011.01.015
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A Comprehensive Genomic Binding Map of Gene and Chromatin Regulatory Proteins in Saccharomyces

Abstract: SUMMARY Hundreds of different proteins regulate and implement transcription in Saccharomyces. Yet their inter-relationships have not been investigated on a comprehensive scale. Here we determined the genome-wide binding locations of 200 transcription-related proteins, under normal and acute heat shock conditions. This study distinguishes binding between distal versus proximal promoter regions as well as the 3' ends of genes for nearly all mRNA and tRNA genes. This study reveals 1) a greater diversity and speci… Show more

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Cited by 285 publications
(402 citation statements)
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References 59 publications
(73 reference statements)
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“…This overlap in function at these genes supports the idea that Ubp8 modulates the activity of Snf1 to fine-tune the regulation of Snf1 target genes ( Fig. 5A and Table 2) (16,40,45). To more directly determine whether Snf1 activity is affected by Ubp8 loss, we examined the phosphorylation status of a Snf1 target protein.…”
Section: Resultssupporting
confidence: 70%
“…This overlap in function at these genes supports the idea that Ubp8 modulates the activity of Snf1 to fine-tune the regulation of Snf1 target genes ( Fig. 5A and Table 2) (16,40,45). To more directly determine whether Snf1 activity is affected by Ubp8 loss, we examined the phosphorylation status of a Snf1 target protein.…”
Section: Resultssupporting
confidence: 70%
“…However, Swi/Snf complex subunits are also found associated with some gene promoters that show constitutive activity in yeast grown in rich medium (41,42). We examined Snf5 association with several such promoters in wild type and srb4/med17 ts yeast (Fig.…”
Section: Dependence Of Swi/snf Complex Recruitment Onmentioning
confidence: 99%
“…Recently the proximal binding of Forkhead transcription factors (Fkh1 and Fkh2) has been implicated in determining early origin activation time (Knott et al 2012). We find that of the 24 origins that replicate early in S. cerevisiae, but later in at least one other sensu stricto species, only seven are reported to be associated with Fkh1 and/or Fkh2 in S. cerevisiae (Supplemental Table S4; Venters et al 2011). Therefore, evolutionary loss of Fkh1/2 association cannot explain the observed difference in replication time for the majority of these origins.…”
Section: Conservation Of Replication Timingmentioning
confidence: 77%