A plump lip is the symbol of youth and glamorousness. Influenced by sun damage, genetic factors, and smoking, aging will cause volume loss and perioral wrinkles to the lip. 1 Lip augmentation with dermal filler is frequently performed to offset the age-related changes and provides a more attractive appearance. 2 Botulinum toxin A (BTA) is a naturally occurring polypeptide chain molecule derived from the Clostridium botulinum bacterium. By blocking the release of acetylcholine at the myoneural junction, BTA inhibits the contraction of orbicularis oris muscle and improves perioral wrinkles. 3 The paralyzed effect that BTA has on the orbicularis oris muscle results in the eversion of the lips and achieves an augmented outcome. 4 This study presents three cases of BTA injection to the lip and evaluates the possible changes in the labial morphology and surface area. 2 | C A S E REP ORT Three individuals (two females and one male) with no previous BTA treatment, with a mean age of 28.7 ± 5.5, received a total of 4U BTA (BOTOX ® , Allergan; 40 U/mL) with 1 unit at each site. The injection sites were located symmetrically at the vermilion border of the upper lip at the dermis level (Figure 1). Vectra ® H1 3D imaging system (Vectra M3, Canfield Scientific Inc) was used to capture 3D photographs of the patients with mouth gently closed in a neutral