2019
DOI: 10.1101/661033
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A Comprehensive Integrated Anatomical And Molecular Atlas Of Rodent Intrinsic Cardiac Nervous System

Abstract: In this study, we developed, coordinated, and integrated several technologies including novel whole organ imaging, software development to support the very first precise 3D neuroanatomical mapping and molecular phenotyping of the intracardiac nervous system (ICN). While qualitative and gross anatomical descriptions of the anatomy of the ICN have been presented, we here bring forth the first comprehensive atlas at large scale of the entire ICN in rat at a single cell resolution. Our work for the first time prov… Show more

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Cited by 2 publications
(2 citation statements)
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“…This very low frequency has been proposed to reflect mainly PNS influence, sympathovagal balance, renin/angiotensin system (Taylor et al 1998), and other unidentified factors (Billman, 2013). Moreover, we cannot neglect the existence of an intrinsic cardiac nervous system (Achanta et al, 2020;Aksu et al, 2021;Fedele and Brand, 2020;Kerna and Anderson 2021;Shen, 2021), and the influence of neuromodulators or hormones , which challenge the simplistic definition of LF/HF as an index of both SNS and PNS components.…”
Section: Cardiac Tone Decreases With Maturationmentioning
confidence: 96%
“…This very low frequency has been proposed to reflect mainly PNS influence, sympathovagal balance, renin/angiotensin system (Taylor et al 1998), and other unidentified factors (Billman, 2013). Moreover, we cannot neglect the existence of an intrinsic cardiac nervous system (Achanta et al, 2020;Aksu et al, 2021;Fedele and Brand, 2020;Kerna and Anderson 2021;Shen, 2021), and the influence of neuromodulators or hormones , which challenge the simplistic definition of LF/HF as an index of both SNS and PNS components.…”
Section: Cardiac Tone Decreases With Maturationmentioning
confidence: 96%
“…Having these types of information on a scaffold contributes to a more thorough understanding of the organ innervation, as well as making the data more accessible and replicable for other scientists. This is a joint effort from multiple researchers to not only produce the data, but also use the data to navigate 2D connectivity maps and build 3D organ scaffolds that can provide a comprehensive brain-organ atlas and "a common coordinate framework for cross-species comparisons" (Achanta et al 2020, Leung et al 2021.…”
Section: Cgrp-ir Axon Innervation Of the Flat-mount Whole Stomach At ...mentioning
confidence: 99%