A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Abstract

This paper aims to update the clinical researches using superparamagnetic iron oxide (SPIO) nanoparticles as magnetic resonance imaging (MRI) contrast agent published during the past five years.

Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

“…Magnetic nanoparticles are already versatilely used in research and partly in clinical issues for hyperthermia or drug delivery in tumor [31][32][33][34][35] and infection treatment [36,37], as contrast agents for magnetic resonance imaging [38][39][40], and others [41,42]. The biocompatibility of certain magnetic nanoparticles with different composition, magnetic properties or size has already been published [43,44].…”

Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s Disease

“…In order to improve the symptoms by drug therapy based on the diagnosis at the early stage of the disease, MRI CAs, especially SPIO and USPIO, have already been developed in imaging and targeting drug delivery. Despite the fact that regulatory bodies have already approved some SPIO agents for many years, the clinical application of these agents has been proven a difficult journey (Wáng and Idée, 2017). For instance, by the end of 2015, only five types of SPIO had been designed and applied in clinical settings as magnetic resonance CAs (Yang et al, 2016).…”

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

“…Mater. [74] LN detection with SPION results in an improved accurate diagnosis of LN metastases both preoperatively and intraoperatively, which may become a cost-effective strategy for clinic applications. [62,63] Many clinical trials have shown favorable results of intraoperative SLN detection with ICG, [64][65][66] even in robotassisted laparoscopic surgery.…”

“…[58,72,73] The benefits of SPION for LN detection include their availability by both intravenous and interstitial administrations, which facilitate preoperative biopsy with magnetic resonance imaging (MRI) and intraoperative SLN dissection guidance for further histopathological evaluations with a simple hand-hold probe. [74] LN detection with SPION results in an improved accurate diagnosis of LN metastases both preoperatively and intraoperatively, which may become a cost-effective strategy for clinic applications. [75][76][77] These benefits of SPION can also be the potential benefits of other NMs for IGS-based LN detection.…”