“…Severe cases are recommended for surgical intervention to provide support to the pelvic floor using mid-urethral slings with synthetic sub-urethral tape or mesh ( Oliphant et al, 2009 ; Dwyer and Karmakar, 2019 ), which remains the most common surgical procedure for patients with SUI with success rate of 72–77% at 24 months ( Imamura et al, 2019 ). Unfortunately, 12% of those implanted with SUI slings suffer from at least one serious adverse event such as pain, mesh exposure, dyspareunia, voiding dysfunction, urge incontinence, vaginal wall erosion, or recurrent urinary tract infections ( Gomes et al, 2017 ; Gurol-Urganci et al, 2018 ; FDA, 2019 ; Keslar et al, 2020 ), and approximately 4% of patients have to adjust or remove the implant 60 months after initial surgery ( Clancy et al, 2019 ; Brennand et al, 2020 ). Understanding the anatomy and physiology of individual components will pave the way for the development of personalized diagnosis and more effective treatment options in pelvic floor disorders.…”