IntroductionTo analy ze and handle quality problem during product development and manufacture holds significant value to the quality improvement. Fo r the complex products, such as aerospace vehicle, airplane, missile, railway vehicle and steamship etc, the mechanis m of the quality problem is more co mplex because of the various customer requirements, sophisticated components, high-end technology and challenging management (LI Bohu, 2002). The quality control of complex products is an interdisciplinary, co mplex and long cycle proces s (Zhang Genbao, 2010). For a long time, how to analyze and deal with quality problem in co mp lex product development and manufacture has become the co mmon focus of both academia and industry. A lot o f works have been done in the process of the quality problem handling and prevention. A co mprehensive model was proposed for process selection by JERUSALEM MA, th is model integrated quality, cost, and delivery time as well as offline and online quality control (JERUSA LEM, 2016 ). The PDCA wh ich is possible to use for the continuous quality improvement of products, processes and services in organizations is introduced by M. So kovic (M. Sokov ic, 2010). Six sig ma is a measure of quality that strives for near eliminat ion of defects using the application of statistical methods (Jiju Anton, 2004). The Po ka-Yo ke method is to eliminate or min imize hu man erro rs in manufacturing processes and management as a result of mental and physical hu man imperfections (M. Dudek-Burliko wska, 2009). The methods which mentioned above are focused on quality prob lem management with standard processing procedures; they are lack of the combining of the management resources and technology resources. Given this, the quality problem processing framework named "Quality Problem Closed Loop" has been introduced in this paper. The framewo rk has arisen in China aerospace industry and attracted wide attention fro m academia (QJ3183-2003). Quality Prob lem Closed Loop (QPCL) was first put forward in 1990s and was defined as: "The quality problems arising in periods of design, production, experiment and service should be analyzed and corrected in both technology aspect and management aspects, and preventive measures should be taken to avoid the repetitions of potential problems with similar context (QJ3183-2003 China)". QCs-linkage model was constructed to describe the relationships and based on which a quality problem p rocessing framewo rk was proposed (Duan, 2013 Abstract To analyze and handle quality problem during product development and manufacture, a holonic quality problem closed loop (HQPCL) framework is proposed in this paper. Some holons which encapsulate the technology resources and management resources are built in the HQPCL. A series of holonic units such as quality problem locating holon, quality problem source-tracing holon, quality problem mitigation holon, quality problem closed loop holon and assist holons were built. A sequence diagram of the HQPCL was given by the UML (Unified Modeli...