A Comprehensive Non-targeted Analysis Study of the Prenatal Exposome

Abrahamsson, Dimitri; Wang, Aolin; Jiang, Ting; Wang, Miaomiao; Siddharth, Adi; Morello‐Frosch, Rachel; Park, June-Soo; Sirota, Marina; Woodruff, Tracey J.

doi:10.1021/acs.est.1c01010

Cited by 45 publications

(43 citation statements)

References 52 publications

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“…Building on NTA steps from prior studies 4,6,13 , we confirmed and quantified the presence of nine chemicals, some of which have not been previously measured in pregnant people, such tridecanedioic acid, octadecanedioic acid, and tetraethylene glycol, or rarely measured in pregnant people like 4nitrophenol. In addition, a subset of these were moderately to strongly associated with GDM and hypertensive disorders of pregnancy.…”

Section: Discussionmentioning

confidence: 61%

“…The selection and confirmation procedures for selection of these chemicals is described elsewhere. 5,6,13 Briefly, in previous NTA studies, 30 matched maternal and cord samples were scanned using HRMS in positive and negative ionization modes identifying suspect features. Detected features were matched to an in-house database and features were then prioritized for MS/MS fragmentation based on the ubiquity of exposure, feature intensity differences across demographic variables, and correlation between maternal and cord samples.…”

Section: Methodsmentioning

confidence: 99%

“…5,6 NTA studies in pregnant and non-pregnant populations have identified both known and novel chemical exposures, including PFAS congeners, pesticides, flame retardants, and other industrial chemicals, which have been linked with pregnancy complications. 6,7 For example, PFAS has been linked with increased risk of miscarriage and preeclampsia, 8 and chemicals with fatty acid-like structures, including PFAS and other long-chain hydrocarbons, have been shown to interact with endogenous fatty acid metabolism impacting placental development and may contribute to pregnancy complications and adverse birth outcomes. 6,[9][10][11] Similarly, NTA studies have been able to link novel chemical exposures and metabolism biomarkers.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 For example, PFAS has been linked with increased risk of miscarriage and preeclampsia, 8 and chemicals with fatty acid-like structures, including PFAS and other long-chain hydrocarbons, have been shown to interact with endogenous fatty acid metabolism impacting placental development and may contribute to pregnancy complications and adverse birth outcomes. 6,[9][10][11] Similarly, NTA studies have been able to link novel chemical exposures and metabolism biomarkers. 6,12 However, the vast majority of novel chemicals identified through NTA have not been evaluated for associations with pregnancy related complications.…”

Section: Introductionmentioning

confidence: 99%

“…6,[9][10][11] Similarly, NTA studies have been able to link novel chemical exposures and metabolism biomarkers. 6,12 However, the vast majority of novel chemicals identified through NTA have not been evaluated for associations with pregnancy related complications.…”

Section: Introductionmentioning

confidence: 99%

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Extending non-targeted exposure discovery of environmental chemical exposures during pregnancy and their association with pregnancy complications—a cross-sectional study

Trowbridge

Abrahamsson

Jiang

et al. 2022

Preprint

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Background: Non-targeted Analysis (NTA) methods can identify novel exposures in a variety of biological matrices, however, few have been assessed for relationships with pregnancy complications. Objectives: This study characterizes levels of nine exogenous and endogenous chemicals including linear and branched isomers perfluorooctane sulfonate (PFOS); perfluorohexane sulfonate (PFHxS); monoethylhexyl phthalate; 4-nitrophenol; and tetraethylene glycol; the fatty acids: tridecanedioic acid and octadecanedioic acid, and the bile acid: deoxycholic acid. These chemicals were identified, selected, and confirmed in prior NTA steps and we evaluate their relationship with pregnancy complications in a diverse pregnancy cohort in San Francisco. Methods: Matched maternal and cord serum samples were collected from 302 pregnant people at delivery from the Chemicals in Our Bodies cohort in San Francisco. Chemicals were identified via NTA and quantified using targeted approaches. We calculate distributions and Spearman correlation coefficients testing the relationship of chemicals within and between the maternal and cord blood matrices. Among the maternal samples we used logistic regression to calculate the odds of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy associated with prenatal chemical exposures. Results: We detected linear PFOS, PFHxS, tridecanedioic acid, and deoxycholic acid in at least 97% of maternal samples. We observed strong correlations between cord and maternal levels of PFHxS (coefficient = 0.9), linear PFOS (0.8), and branched PFOS (0.8). In maternal samples, branched PFOS was correlated with linear PFOS (0.8) and PFHxS (0.6). We found Linear PFOS and branched PFOS were positively associated with increased odds of GDM [OR (95%CI): 1.60 (0.94, 2.73) and 1.56 (1.00 , 2.44) respectively] and tridecanedioic acid was positively associated with hypertensive disorders of pregnancy [1.71 (0.79 , 3.82 )]. Discussion: Chemicals measured in this study were identified through NTA and targeted quantification. We identified endogenous and exogenous chemicals some of which have seldom been quantified in pregnant people.

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Section: Discussionmentioning

confidence: 61%