A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

Ahmed, Shabina Ishtiaq; Jamil, Sehrish; Ismatullah, Humaira; Hussain, Rashid; Bibi, Shabana; Khandaker, Mayeen Uddin; Naveed, Aisha; Idris, Abubakr M.; Emran, Talha Bin

doi:10.1016/j.sjbs.2023.103561

Cited by 4 publications

(2 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The analysis of organic compounds in Sphagnum fallax moss extract was carried out using standard methods [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

Advances in the Toxicity Assessment of Silver Nanoparticles Derived from a Sphagnum fallax Extract for Monolayers and Spheroids

Iskuzhina,

Batasheva,

Kryuchkova

et al. 2024

Biomolecules

View full text Add to dashboard Cite

The production of nanomaterials through environmentally friendly methods is a top priority in the sustainable development of nanotechnology. This paper presents data on the synthesis of silver nanoparticles using an aqueous extract of Sphagnum fallax moss at room temperature. The morphology, stability, and size of the nanoparticles were analyzed using various techniques, including transmission electron microscopy, Doppler laser velocimetry, and UV-vis spectroscopy. In addition, Fourier transform infrared spectroscopy was used to analyze the presence of moss metabolites on the surface of nanomaterials. The effects of different concentrations of citrate-stabilized and moss extract-stabilized silver nanoparticles on cell viability, necrosis induction, and cell impedance were compared. The internalization of silver nanoparticles into both monolayers and three-dimensional cells spheroids was evaluated using dark-field microscopy and hyperspectral imaging. An eco-friendly method for the synthesis of silver nanoparticles at room temperature is proposed, which makes it possible to obtain spherical nanoparticles of 20–30 nm in size with high bioavailability and that have potential applications in various areas of human life.

show abstract

“…The analysis of organic compounds in Sphagnum fallax moss extract was carried out using standard methods [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

Advances in the Toxicity Assessment of Silver Nanoparticles Derived from a Sphagnum fallax Extract for Monolayers and Spheroids

Iskuzhina,

Batasheva,

Kryuchkova

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

“…[ 27 ]. This may show that N. sativa seed oil and its active constituent TQ have a potent antiviral effect against murine cytomegalovirus infection, which may be due to the upregulation of IFN-g and macrophage activation [ 28 ]. It could be used as a potential co-therapeutic agent against numerous conditions related to immunodeficiency [ 6 ].…”

Section: An Introduction To Thymoquinone and Viral Diseasesmentioning

confidence: 99%

Cellular, Molecular, Pharmacological, and Nano-Formulation Aspects of Thymoquinone—A Potent Natural Antiviral Agent

et al. 2023

View full text Add to dashboard Cite

The goal of an antiviral agent research is to find an antiviral drug that reduces viral growth without harming healthy cells. Transformations of the virus, new viral strain developments, the resistance of viral pathogens, and side effects are the current challenges in terms of discovering antiviral drugs. The time has come and it is now essential to discover a natural antiviral agent that has the potential to destroy viruses without causing resistance or other unintended side effects. The pharmacological potency of thymoquinone (TQ) against different communicable and non-communicable diseases has been proven by various studies, and TQ is considered to be a safe antiviral substitute. Adjunctive immunomodulatory effects in addition to the antiviral potency of TQ makes it a major compound against viral infection through modulating the production of nitric oxide and reactive oxygen species, decreasing the cytokine storm, and inhibiting endothelial dysfunction. Nevertheless, TQ’s low oral bioavailability, short half-life, poor water solubility, and conventional formulation are barriers to achieving its optimal pharmacologic benefits. Nano-formulation proposes numerous ways to overcome these obstacles through a small particle size, a big surface area, and a variety of surface modifications. Nano-based pharmaceutical innovations to combat viral infections using TQ are a promising approach to treating surmounting viral infections.

show abstract

Anti‐inflammatory effects of natural products from vitamin C‐rich fruits

Chan,

Xiong,

Zhao

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

Inflammation is a crucial target for therapeutic interventions in many life‐threatening diseases, which sustains ongoing interest in the field of inflammation biology. Plant‐derived natural products, rich in phytochemicals, have been used as healing agents in several diseases since antiquity. These compounds exhibit antioxidant, anti‐inflammatory, and immunomodulatory properties, as well as gut microbiota modulation. They hold substantial potential as promising candidates for the development of novel strategies in the management of inflammation‐associated diseases. This study presents a comprehensive overview of the potential benefits given from administrating natural products (e.g., phenols, terpenes, flavonoids, and saccharides), with a particular emphasis on vitamin C‐rich fruits based on the high content of bioactive compounds with anti‐inflammatory properties. Apart from natural products, the gut microbiota acts a significant role in modulating the activation of inflammatory reaction. Deviations in its composition have been associated with various diseases. Furthermore, advancements in machine learning contribute to enhancing clinical outcomes in disease treatment. Therefore, this work provided some valuable insights in elaborating the therapeutic potential of vitamin C‐rich fruits, the role of probiotics as anti‐inflammatory agents, and the utilization of computer‐aided drug design techniques.

show abstract

A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

Cited by 4 publications

References 163 publications

Advances in the Toxicity Assessment of Silver Nanoparticles Derived from a Sphagnum fallax Extract for Monolayers and Spheroids

Advances in the Toxicity Assessment of Silver Nanoparticles Derived from a Sphagnum fallax Extract for Monolayers and Spheroids

Cellular, Molecular, Pharmacological, and Nano-Formulation Aspects of Thymoquinone—A Potent Natural Antiviral Agent

Anti‐inflammatory effects of natural products from vitamin C‐rich fruits

Contact Info

Product

Resources

About