A Comprehensive Review of Advanced Biopolymeric Wound Healing Systems

Mayet, Naeema; Choonara, Yahya E.; Kumar, Pradeep; Tomar, Lomas K.; Tyagi, Charu; Toit, Lisa C. du; Pillay, Viness

doi:10.1002/jps.24068

Cited by 248 publications

(138 citation statements)

References 152 publications

(323 reference statements)

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“…The underlying dermis, separated from the epidermis by a basement membrane, is mainly composed of ECM molecules arranged in a dense matrix of connective tissue rich in collagen and elastin fibres that provides structural and mechanical support to the skin [15]. It is a highly dynamic, vascularized layer that supports the epidermis, provides flexibility and strength to the skin, and also contains blood vessels, sweat and sebaceous glands, hair follicles and sensory receptors [13,115]. The predominant cells in dermis are heterogeneous subpopulations of fibroblasts, which are responsible for the production of connective tissue components [40].…”

Section: Skin Structure and Constituentsmentioning

confidence: 99%

“…Other cell types like mast cells and macrophages are also present, playing important roles in immune and inflammatory responses [13,79]. The hypodermis, which acts as an energy source and heat insulator, is located just below the dermis and is mainly composed of adipose tissue and collagen, attaching the dermis to underlying tissues [13,115].…”

Section: Skin Structure and Constituentsmentioning

confidence: 99%

“…To extend their efficacy, facilitate their handling and improve their impact on the wound, most of these therapeutic compounds have been embedded within gauzes or incorporated within dressing materials [2,77]. More advanced products, like traditional and modern dressings, represent a cost-effective therapy to protect the wound from the external environment and to prevent wound contamination and dehydration [115,150]. Due to their high water absorption rates, adhesion to the wound bed and increased pain during dressing changes, traditional dressings (e.g., gauze, cotton wool) are often employed as secondary dressings to allow the exudate drainage and to support the application of more effective products (e.g., skin substitutes) [77,115].…”

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

“…More advanced products, like traditional and modern dressings, represent a cost-effective therapy to protect the wound from the external environment and to prevent wound contamination and dehydration [115,150]. Due to their high water absorption rates, adhesion to the wound bed and increased pain during dressing changes, traditional dressings (e.g., gauze, cotton wool) are often employed as secondary dressings to allow the exudate drainage and to support the application of more effective products (e.g., skin substitutes) [77,115]. Traditional dressings have been largely replaced by modern dressings, which are capable of creating and maintaining a moist environment in the wound bed, ideally suited for cellular migration and proliferation [81,115,124,150,151].…”

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

“…Due to their high water absorption rates, adhesion to the wound bed and increased pain during dressing changes, traditional dressings (e.g., gauze, cotton wool) are often employed as secondary dressings to allow the exudate drainage and to support the application of more effective products (e.g., skin substitutes) [77,115]. Traditional dressings have been largely replaced by modern dressings, which are capable of creating and maintaining a moist environment in the wound bed, ideally suited for cellular migration and proliferation [81,115,124,150,151]. A great deal of interest has been focused on advanced dressings with the ability to release bioactive substances directly into the wound bed [6,75,161,192].…”

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

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Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in predefined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations in terms of fully replicating the cellular and extracellular matrix (ECM) heterogeneity in native skin. The success of bioprinting for skin repair strongly depends on the design of printable bioinks capable of supporting the function of printed cells and stimulating the production of new ECM components. To better mimic the human skin, novel developments in dedicated bioprinting technologies, in the design of bioinks, as well as in the printing of vascularised constructs are necessary. This paper presents an overview regarding the use of bioprinting for skin tissue engineering applications. The operating principles of bioprinting technologies are outlined along with requirements of printed skin constructs. Finally, preclinical results are summarized and future perspectives for the field are highlighted.

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Section: Skin Structure and Constituentsmentioning

confidence: 99%

Section: Skin Structure and Constituentsmentioning

confidence: 99%

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

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Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Wounds

2019

Common Clinical Presentations in Dogs and Cats

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Advances in Skin Regeneration: Application of Electrospun Scaffolds

Norouzi

Boroujeni

Omidvarkordshouli

et al. 2015

Adv Healthcare Materials

242

182

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The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed.

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A Comprehensive Review of Advanced Biopolymeric Wound Healing Systems

Cited by 248 publications

References 152 publications

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

Wounds

Advances in Skin Regeneration: Application of Electrospun Scaffolds

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