A comprehensive review of bioactive peptides obtained from animal byproducts and their applications

Bechaux, Julia; Gatellier, Philippe; Page, Jean-François Le; Drillet, Yoan; Santé-Lhoutellier, Véronique

doi:10.1039/c9fo01546a

Cited by 111 publications

(68 citation statements)

References 167 publications

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“…To date, bioactive peptides have shown several therapeutic effects such as antihypertensive, antioxidant, antimicrobials, and antiproliferative effects derived from hydrolysates of meat and fish proteins [66,67]. In addition, other biological activities of bioactive peptides such as antithrombotic, opioid activities, cholesterol-lowering ability, immunomodulating effect, antidiabetic activity, etc., have also been reported by several authors [111,113,114]. Moreover, protein hydrolysates are usually produced by enzymatic hydrolysis of whole protein sources by appropriate proteolytic enzymes under controlled conditions, followed by post-hydrolysis processing to isolate desired and potent bioactive peptides from a complex mixture of active and inactive peptides [111].…”

Section: Bioactive Peptides and Protein Hydrolysatementioning

confidence: 99%

Fish-Based Bioactives as Potent Nutraceuticals: Exploring the Therapeutic Perspective of Sustainable Food from the Sea

et al. 2020

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Recent developments in nutraceuticals and functional foods have confirmed that bioactive components present in our diet play a major therapeutic role against human diseases. Moreover, there is a huge emphasis on food scientists for identifying and producing foods with better bioactive activity, which can ultimately provide wellness and well-being to human health. Among the several well-known foods with bioactive constituents, fish has always been considered important, due to its rich nutritional values and by-product application in food industries. Nutritionists, food scientists, and other scientific communities have been working jointly to uncover new bioactive molecules that could increase the potential and therapeutic benefits of these bioactive components. Despite the innumerable benefits of fish and known fish bioactive molecules, its use by food or pharmaceutical industries is scarce, and even research on fish-based nutraceuticals is not promising. Therefore, this review focuses on the current information/data available regarding fish bioactive components, its application as nutraceuticals for therapeutic purposes in the treatment of chronic diseases, ethnic issues related to consumption of fish or its by-products. Especial emphasis is given on the utilization of fish wastes and its by-products to fulfill the world demand for cheap dietary supplements specifically for underdeveloped/least developed countries.

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Section: Bioactive Peptides and Protein Hydrolysatementioning

confidence: 99%

Fish-Based Bioactives as Potent Nutraceuticals: Exploring the Therapeutic Perspective of Sustainable Food from the Sea

et al. 2020

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“…We review peptides from milk, egg, and soy. Peptides from legumes [233], vegetables [234], and meat [235,236] were recently reviewed elsewhere (Figure 2).…”

Section: Food-derived Bioactive Peptides In Obesity and Related Metabmentioning

confidence: 99%

Peptides from Natural or Rationally Designed Sources Can Be Used in Overweight, Obesity, and Type 2 Diabetes Therapies

et al. 2020

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Overweight and obesity are among the most prominent health problems in the modern world, mostly because they are either associated with or increase the risk of other diseases such as type 2 diabetes, hypertension, and/or cancer. Most professional organizations define overweight and obesity according to individual body–mass index (BMI, weight in kilograms divided by height squared in meters). Overweight is defined as individuals with BMI from 25 to 29, and obesity as individuals with BMI ≥30. Obesity is the result of genetic, behavioral, environmental, physiological, social, and cultural factors that result in energy imbalance and promote excessive fat deposition. Despite all the knowledge concerning the pathophysiology of obesity, which is considered a disease, none of the existing treatments alone or in combination can normalize blood glucose concentration and prevent debilitating complications from obesity. This review discusses some new perspectives for overweight and obesity treatments, including the use of the new orally active cannabinoid peptide Pep19, the advantage of which is the absence of undesired central nervous system effects usually experienced with other cannabinoids.

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“…Protein residues from industrial processes are potentially high interest sources, due to abundant byproduct availability, such as bioactive peptides produced by hydrolysis 1 . Proteins and peptides are the major molecular constituent of living organisms.…”

Section: Introductionmentioning

confidence: 99%

Tri‐ and dipeptides identification in whey protein and porcine liver protein hydrolysates by fast LC–MS/MS neutral loss screening and de novo sequencing

et al. 2021

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We describe a fast (5 min) liquid chromatography tandem mass spectrometry method (LC–MS/MS) based on a 46 Da neutral loss of formic acid (H2O and CO) to identify tri‐ and dipeptides (DIPEP) in whey protein and porcine liver protein hydrolysates and confirmed by further de novo sequencing. Sample solutions were acidified to favor [dipep + H]+ ions, and a m/z range of 50–300 was used to improve sensitivity. All dipeptide candidates were selected based on all possibilities of the 20 amino acid combinations, and their collision‐induced dissociation fragments were screened via de novo sequencing. To determine their biological activities, sequenced dipeptides were compared with the Biopep database and other data from literature. Altogether, 18 dipeptides and 7 tripeptides were identified from the whey protein hydrolysate; they seemed to be broadly active, and peptides were identified as active dipeptidyl peptidase IV inhibitors and active angiotensin‐converting enzyme (ACE), according to available information. Porcine liver hydrolysate showed 14 dipeptides which exhibit similar biological activities to whey protein hydrolysate.

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A comprehensive review of bioactive peptides obtained from animal byproducts and their applications

Abstract: Livestock generates high quantities of residues, which has become a major socioeconomic issue for the meat industry.

Cited by 111 publications

References 167 publications

Fish-Based Bioactives as Potent Nutraceuticals: Exploring the Therapeutic Perspective of Sustainable Food from the Sea

Fish-Based Bioactives as Potent Nutraceuticals: Exploring the Therapeutic Perspective of Sustainable Food from the Sea

Peptides from Natural or Rationally Designed Sources Can Be Used in Overweight, Obesity, and Type 2 Diabetes Therapies

Tri‐ and dipeptides identification in whey protein and porcine liver protein hydrolysates by fast LC–MS/MS neutral loss screening and de novo sequencing

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