A comprehensive review of chloropropanol analytical method in the context of food safety

Zhao, Jinwei; Qin, Chengrong; Shen, Yifan; Xu, Cheng; Yao, Shuangquan; Liang, Chen

doi:10.1016/j.foodchem.2024.138776

Food Chemistry

2024

DOI: 10.1016/j.foodchem.2024.138776

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A comprehensive review of chloropropanol analytical method in the context of food safety

Jinwei Zhao,

Chengrong Qin,

Yifan Shen

et al.

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Cited by 2 publications

References 64 publications

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SiO2-based molecularly imprinted polymer composites and its application in fluorescence sensor analysis of 3-chloro-1,2-propanediol in paper food contact materials

Zhao,

Xu,

Liu

et al. 2024

Adv Compos Hybrid Mater

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SiO2-based molecularly imprinted polymer composites and its application in fluorescence sensor analysis of 3-chloro-1,2-propanediol in paper food contact materials

Zhao,

Xu,

Liu

et al. 2024

Adv Compos Hybrid Mater

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Determination of Free Glycidol and Total Free Monochloropropanediol in Fish and Krill Oil with Simple Aqueous Derivatization and High-Performance Liquid Chromatography–Tandem Mass Spectrometry

Yang,

Tang,

Liu

et al. 2024

Foods

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This study introduces a novel method for detecting free glycidol and total free monochloropropanediol (MCPD) in fish and krill oil. Before analysis on high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS), p-(dimethylamino)phenol was used for derivatization of these compounds, enabling the sensitive determination of these contaminants. The sample preparation procedure includes a simple, efficient pretreatment using NaCl aqueous solution extraction and C18 sorbent cleanup (for demulsification), distinguishing glycidol from MCPD under varied reaction conditions for derivatization (weak acidic and strong alkaline aqueous environments). This approach shows broad linearity from 1 to at least 256 ng·mL−1, improved sensitivity compared to standard GC-MS methods, with the limit of detection (LOD) and limit of quantification (LOQ) for MCPD and glycidol in both oil samples verified at 0.5 ng·mL−1 and 1 ng·mL−1, respectively. Different from previous HPLC-MS methods for direct detection of glycidol esters or MCPD esters, this is the first HPLC-MS method used for the detection of free glycidol and total free MCPD in edible oil. Furthermore, this method can be potentially developed for glycidol or monochloropropane diol esters, which is similar to the current official methods adopted for indirect detection of these contaminants in different food matrices. Application of this detection method to real dietary supplements (fish oil and krill oil) revealed MCPD residues in fish oil (maximum detected: 32.78 ng·mL−1) and both MCPD (maximum detected: 2767.3 ng·mL−1) and glycidol (maximum detected: 22.2 ng·mL−1) in krill oil, emphasizing its effectiveness and accuracy for assessing contamination in these supplements.

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A comprehensive review of chloropropanol analytical method in the context of food safety

Cited by 2 publications

References 64 publications

SiO2-based molecularly imprinted polymer composites and its application in fluorescence sensor analysis of 3-chloro-1,2-propanediol in paper food contact materials

SiO2-based molecularly imprinted polymer composites and its application in fluorescence sensor analysis of 3-chloro-1,2-propanediol in paper food contact materials

Determination of Free Glycidol and Total Free Monochloropropanediol in Fish and Krill Oil with Simple Aqueous Derivatization and High-Performance Liquid Chromatography–Tandem Mass Spectrometry

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