A comprehensive review of Combretum flavonoids and their biological activities: An update between 1990 and 2022

Umoh, Sampson D.; Bojase, Gomotsang; Masesane, Ishmael B.; Loeto, Daniel; Majinda, Runner T.

doi:10.1016/j.bse.2023.104644

Cited by 5 publications

(6 citation statements)

References 45 publications

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“…The chemical composition of C. micranthum is rich and varied, including compounds such as polyphenols, flavonoids, tannins, triterpenes, steroids, and alkaloids [5][6][7][8]. The leaves of the plant contain a diversity of molecular families, each contributing to its beneficial health effects.…”

Section: Introductionmentioning

confidence: 99%

“…The leaves of the plant contain a diversity of molecular families, each contributing to its beneficial health effects. Scientific studies [9,10] have highlighted the pharmaceutical benefits of C. micranthum, demonstrating its nephroprotective [11], anti-inflammatory [12], antioxidant [9][10][11][12][13][14], antimicrobial [15], antiviral [16], antimalarial [17], and antidiabetic properties [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Furthermore, the cosmetic applications of C. micranthum are beginning to be explored due to its depigmenting [19], moisturizing, anti-inflammatory, and repair of UV-induced damage properties [20].…”

Section: Introductionmentioning

confidence: 99%

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Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Messaili,

Haggouch,

Bignard

et al. 2024

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Combretum micranthum, a plant native to Africa, has a well-documented traditional use in the treatment of various ailments such as fever, diabetes, and malaria. Its pharmaceutical benefits include nephroprotective, anti-inflammatory, antioxidant, and antimicrobial properties, which were proven. In addition, its potential for cosmetic applications is being explored due to its depigmenting, anti-inflammatory, and UV-damage-repairing properties. This article investigates the molecular composition and new cosmetically relevant biological activity of C. micranthum and enriched fractions to begin the establishment of the structure–activity relationship. Firstly, an extract of C. micranthum was prepared and selected for its overall biological response and then fractionated to obtain simplified molecular fractions. One fraction was particularly enriched in kinkeloids, a specific family of compounds to this species. All the fractions and the crude extract were then tested on biological targets to evaluate and compare their cosmetic activities. Molecular networks were constructed from the UHPLC-MS/HRMS data to better characterize the extract and fractions and to highlight structure–activity relationships. This study highlights the metabolic profiling of a butylene glycol extract of C. micranthum, showing its main chemical families and revealing that the kinkeloids, identified by HRMS and NMR, promote an increase in collagen I synthesis, an interesting cosmetic activity neither previously described for these compounds and neither for C. micranthum extract.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Messaili,

Haggouch,

Bignard

et al. 2024

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“…One such plant is Combretum racemosum, belonging to the Combretaceae family and commonly found in Sub-Saharan Africa. This medicinal plant has been the focus of various studies, revealing its rich array of bioactive compounds [12][13][14][15][16]. Species within the Combretum genus are particularly noted for their significant anticancer properties [17,18].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Property and Cytotoxic Effect Showing Antiproliferative Potency in Human Melanoma Cell Lines (A375) of Combretum racemosum P. Beauv. Leaf and Root Extracts Used in Benin

Dah-Nouvlessounon,

Chokki,

Hoteyi

et al. 2023

Antioxidants

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Combretum racemosum, a plant from the Combretaceae family, is traditionally used in Benin for various health problems. However, scientific research on Beninese samples of this plant is limited. The aim of this study was to identify and assess the bioactive compounds in the plant’s leaves and roots. Initial screening involved analyzing powders derived from these parts for total polyphenols, flavonoids, and both condensed and hydrolyzable tannins. The polyphenolic compounds were analyzed using HPLC-DAD-ESI-MS. To evaluate the plant’s antimicrobial properties, the agar diffusion method was employed, while FRAP and DPPH assays were used to determine its antioxidant capacity. For anti-inflammatory activity, the study utilized tests for in vitro protein denaturation inhibition and in vivo acute edema induced by carrageenan. Additionally, an antiproliferative assay was conducted using the human melanoma cell line A375. The analysis revealed the presence of significant polyphenolic compounds in both the leaf and root extracts of C. racemosum. Notably, compounds like Pedunculagin, Vescalagin, Casuarictin, and Digalloyl-glucoside were abundant in the leaves, with Vescalagin being especially predominant in the roots. The study also found that the dichloromethane extracts from the leaves and roots exhibited bactericidal effects on a substantial percentage of meat-isolated strains. Moreover, the antioxidant activities of these extracts were confirmed through FRAP and DPPH methods. Interestingly, the dichloromethane root extract showed strong activity in inhibiting thermal albumin denaturation, while the water–ethanol leaf extract demonstrated significant edema inhibition. Finally, the study observed that C. racemosum extracts reduced cell viability in a dose-dependent manner, with leaf extracts showing more pronounced antiproliferative effects than root extracts. These findings highlight the potential of C. racemosum leaves and roots as sources of compounds with diverse and significant biological activities. In conclusion, C. racemosum’s leaves and roots exhibit promising biological activities, highlighting their potential medicinal value.

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“…In our continuous search for bioactive (antimicrobial) agents from species of the Combretum genus, it was observed that flavones constitute the largest subclass of flavonoids identified in the Combretum genus. Where flavonoids are the second largest constituent in the genus [1]. Unfortunately, these compounds are isolated in small amounts despite the specific biological actions of flavonoid derivatives, such as antioxidant, antimicrobial, anticancer, and estrogenic activity [1], which are of interest to This emphasis is to further project the possible importance of 7-position substitution in the biological activity of flavones.…”

Section: Introductionmentioning

confidence: 99%

“…Where flavonoids are the second largest constituent in the genus [1]. Unfortunately, these compounds are isolated in small amounts despite the specific biological actions of flavonoid derivatives, such as antioxidant, antimicrobial, anticancer, and estrogenic activity [1], which are of interest to This emphasis is to further project the possible importance of 7-position substitution in the biological activity of flavones. For ecological conservation and the search for a larger sample size, the interest in creating synthetic processes that will make it simple to obtain these flavonoids and their derivatives for biological activity studies has received attention at the University of Botswana [4,5] and from the synthetic community in recent times [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Investigation of the Lewis Acid-Mediated Reactions of Phenols and Ethyl Phenylpropiolate as a Synthetic Route to Flavonoids and Antimicrobial Profile of the Resultant 7-Hydroxy-4-Phenyl-2h-Chromen-2-One and Analogs

Umoh,

Bojase,

Masesane

et al. 2023

JCSN

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Synthetic chemists are increasingly exploring alternative routes to target products, considering factors like environmental threats, side product formation, cost, and efficiency. This is coupled with the health challenges that require urgent responses from new chemical entities. In this context, antimicrobial resistance has exacerbated global diseases, making them difficult to treat with prescribed drugs and causing a persistent public health crisis. These triggered our interest in the search for alternative antimicrobial agents, exploring different synthetic strategies for known bioactive natural compounds for further investigations. In this study, Lewis acid catalyst (FeCl3) and tetrahydrofuran as solvents in the one-pot synthesis of (neo)flavonoid derivatives from readily available phenols and ethyl phenylpropiolate were discovered to afford the coumarins in yields of 43–95%. The synthetic derivatives of 7-hydroxy-4-phenyl-2H-chromen-2-one and analogs obtained were biologically investigated for antimicrobial activity. The compounds showed moderate to poor antimicrobial activity. The effects of different substituents (-R) on the yield of the reaction are also discussed. Future studies should enhance the yield of derivative products and use different assay models for biological activity studies to fully explore the compounds` biorelevance.

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A comprehensive review of Combretum flavonoids and their biological activities: An update between 1990 and 2022

Cited by 5 publications

References 45 publications

Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Metabolite Profiling and Molecular Network Shows Kinkeloids as Promoting of Collagen Synthesis from Combretum micranthum

Pharmacological Property and Cytotoxic Effect Showing Antiproliferative Potency in Human Melanoma Cell Lines (A375) of Combretum racemosum P. Beauv. Leaf and Root Extracts Used in Benin

Preliminary Investigation of the Lewis Acid-Mediated Reactions of Phenols and Ethyl Phenylpropiolate as a Synthetic Route to Flavonoids and Antimicrobial Profile of the Resultant 7-Hydroxy-4-Phenyl-2h-Chromen-2-One and Analogs

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