A comprehensive review of Dynamic Chemical Labelling on Luminex xMAP technology: a journey towards Drug-Induced Liver Injury testing

Abstract

By integrating Dynamic Chemical Labelling (DCL) with Luminex xMAP technology, it becomes feasible to analyse miRs through single- and multi-plex assays, as well as to simultaneously analyse proteins and miRs.

SA-ODG platform: a semi-automated and PCR-free method to analyse microRNAs in solid tissues

“…It was used to analyse circulating miR-122-5p in serum samples from patients with drug-induced liver injury, as well as to analyse miR-451a-5p in whole blood samples and miR-21-5p in cell lysates and plasma. 18,20–22,24–32 In addition, DCL has been applied to detect a variety of pathogens, including viruses and parasites, and can also analyse alpha satellite DNA in in situ hybridization. 33–36…”