A comprehensive review of ethnopharmacological uses, phytochemistry, biological activities, and future prospects of Nigella glandulifera

Zheng, Yang; Zhang, Qiao; Hu, Xiurong

doi:10.1007/s00044-020-02558-9

Cited by 16 publications

(32 citation statements)

References 52 publications

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“…The seeds of Nigella glandulifera Freyn et Sint ( N. glandulifera ), which were known as black cumin (black seeds) and were widely used as a traditional medicine for the treatment of numerous inflammatory diseases (Zheng et al 2020 ). N. glandulifera seed powder, extracts (ethanolic, volatile oil, total flavonoids, and total saponins, etc.…”

Section: Introductionmentioning

confidence: 99%

Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice

Yang

et al. 2020

AMB Expr

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Nigella A, also named Sieboldianoside A, has been extracted from many kinds of Traditional Chinese Medicine (TCM), such as Nigella glandulifera, Stauntonia chinensis DC., and the leaves of Acanthopanax sieboldianus. Nigella A exhibited potential analgesic, anti-inflammatory, anti-tumor, and antioxidant activities. However, whether Nigella A could treat ulcerative colitis (UC) is still unknown. As saponins always be regarded as the kinds of ingredients that could regulate immunity and intestinal flora. This research aimed to investigate the therapeutic effect of Nigella A on UC and explore its effect on intestinal flora. We noted that Nigella A and Sulfasalazine (SASP) could significantly improve the signs and symptoms, alleviate colonic pathological injury in DSS-induced mice. The changing of many specific bacterial genus such as Lactobacillus, Porphyromonadaceae, Bacteroides and Escherichia might closely related to the recovery of intestinal inflammatory response. This study initially confirmed the therapeutic effect of Nigella A and SASP on DSS-induced colitis by improving the diversity of intestinal microbial composition. Nigella A has the potential to be developed for the treatment of UC and other disorders related to the imbalance of intestinal flora.

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Section: Introductionmentioning

confidence: 99%

Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice

Yang

et al. 2020

AMB Expr

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“…For example, N. glandulifera and TSN were con rmed to exhibit signi cant antioxidant and anti-in ammatory properties (Zhao et al 2013;Zheng et al 2020). Triterpene saponins are the dominant group of anti-in ammatory compounds existed in this ethnomedicinal plant (Hu et al 2014;Hu et al 2020) and Nigella A was a major ingredient of triterpene saponins extracted from N. glandulifera.…”

Section: Discussionmentioning

confidence: 98%

“…It has been reported that saponins always exhibited protective effects against DSS-induced intestinal in ammatory injury fermented with probiotic in animal models (Lu et al 2020;Jang et al 2017). Our previous review revealed that many kinds of extractions of N. glandulifera seeds and some active ingredients always exhibited signi cant antiin ammatory effects and might be effective on various in ammatory diseases (Zheng et al 2020). For example, TSN could be considered to be a potential analgesic, anti-in ammatory, anti-tumor, and antioxidant agent (Zhao et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The content of Nigella A was 60.36 ± 1.25 g/100 g existed in TSN (Zhao et al 2013). Our previous results revealed that saponins were the principal active components of N. glandulifera with the highest content (64.5%) and Nigella A (also named Sieboldianoside A) is a major oleanane triterpenoid saponin isolated from N. glandulifera (Hu et al 2020;Zheng et al 2020). We speculated that it could be used to treat a variety of in ammation-related diseases by regulating ora and immune.…”

Section: Introductionmentioning

confidence: 91%

“…The seeds of Nigella glandulifera Freyn et Sint (N. glandulifera), which were known as black cumin (black seeds) and were widely used as a traditional medicine for the treatment of numerous in ammatory diseases (Zheng et al 2020; Hu et al 2020). N. glandulifera seed powder, extracts (ethanolic, volatile oil, total avonoids, and total saponins, etc.…”

Section: Introductionmentioning

confidence: 99%

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Nigella A ameliorates experimental colitis via interacting with gut microbiota on dextran sulphate sodium (DSS)-induced C57BL/6 mice

Xu¹,

Yang²,

Zheng³

et al. 2020

Preprint

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Nigella A, also named Sieboldianoside A, has been extracted from many kinds of Traditional Chinese Medicine (TCM), such as Nigella glandulifera, Stauntonia chinensis DC., and the leaves of Acanthopanax sieboldianus. Nigella A exhibited potential analgesic, anti-inflammatory, anti-tumor, and antioxidant activities. However, whether Nigella A could treat ulcerative colitis (UC) is still unknown. As saponins always be regarded as the kinds of ingredients that could regulate immunity and intestinal flora. This research aimed to investigate the therapeutic effect of Nigella A on UC and explore its effect on intestinal flora. We noted that Nigella A and SASP could significantly improve the signs and symptoms, alleviate colonic pathological injury in DSS-induced mice. The changing of many specific bacterial genus such as Lactobacillus, Porphyromonadaceae, Bacteroides and Escherichia might closely related to the recovery of intestinal inflammatory response. This study initially confirmed the therapeutic effect of Nigella A and SASP on DSS-induced colitis by improving the diversity of intestinal microbial composition. Nigella A has the potential to be developed for the treatment of UC and other disorders related to the imbalance of intestinal flora.

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Structural Diversity, Spectral Data, and Pharmacological Effects of Genus Nigella

Luan Nguyen,

Anam,

Hofdey Megbes

et al. 2023

Chemistry & Biodiversity

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Nigella is one of the most studied plants because of its pharmacological properties like anti-parasitic, anti-inflammatory, neuro-protective, hepatoprotective, and anti-cancerous. In this study, about 20 species of the genus Nigella were reviewed and among them, N. damascene, N. glandulifera, and N. sativa are widely studied for their phytochemical and pharmacological effects. This review describes the phytochemical composition of the genus Nigella, which constitutes many of the compounds including alkaloids, flavonoids, saponins, and terpenoids. The extracts produced by using different solvents and the isolated compounds displayed a wide range of biological activity. These compounds were identified by different spectral techniques. The spectral detail of some advanced techniques including EIS-MS, UV/VIS, IR, 13 C-NMR, and 1 H-NMR of some important phytoconstituents of Nigella spp. has been compiled for the first time in this review which will be helpful to explore and further investigate the chemical composition of this genus.

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A comprehensive review of ethnopharmacological uses, phytochemistry, biological activities, and future prospects of Nigella glandulifera

Cited by 16 publications

References 52 publications

Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice

Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice

Nigella A ameliorates experimental colitis via interacting with gut microbiota on dextran sulphate sodium (DSS)-induced C57BL/6 mice

Structural Diversity, Spectral Data, and Pharmacological Effects of Genus Nigella

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