A Comprehensive Review of Garcinia pedunculata Roxb. and its Therapeutic Potential

Abstract

: Garcinia pedunculata Roxb. (GP), belonging to family Clusiaceae is an evergreen tree growing in semi-wild conditions, widely distributed throughout the Northeastern part of India. Traditionally, this plant is believed to be of immense medicinal importance and is used for the treatment of various ailments. In Assam, the acidic fruit of GP is effectively used in folklore medicine to treat gastrointestinal disorders and is an integral part of ethnic Assamese cuisine. The ripe fruit, seldom consumed fresh or raw, is cut into thin slices, sun-dried for preservation as it is believed that the medicinal property of the fruit increases as it ages. With much traditional claims and beliefs surrounding this plant, many therapeutic potentials of GP has been explored through research till now including its antioxidant, antibacterial, antifungal, anthelmintic, hypolipidemic, antidiabetic, hepatoprotective, neuroprotective, and nephroprotective properties. Moreover, the presence of polyphenols, flavonoids along with bioactive components like hydroxycitric acid, garcinol, cambogin have also been reported from this plant thereby increasing its research avenues. Even with the available knowledge, there is a huge lacking in understanding of its underlying molecular mechanism responsible for the therapeutic properties, pharmacological mode of action, and its effect in different pathological conditions along with detailed information on its chemical composition. This review mainly aims to summarise the potentially beneficial properties of GP that have already been reported, along with identifying the new avenues that still need to be addressed, thereby increasing the future prospect for in-depth research with this plant, along with its distribution and conservation status.

Relevance of Indian traditional tisanes in the management of type 2 diabetes mellitus: A review

“…: Clusiaceae Local name: Borthekera The sliced and sun-dried fruits are boiled in water and the extract is given to diabetic patients ( Hazarika et al, 2020 , Pari and Saravanan, 2004 , Hakim et al, 1997 ). Cambogin, flavonoids, HCA (-hydroxy citric acid), polyphenols, and garcinol are bioactive ingredients ( Bhattacharjee and Devi, 2021 ). Traditional claims and beliefs about its anti-diabetic properties, molecular mechanism, and pharmacological mode of action are not clear over time ( Bhattacharjee and Devi, 2021 ).…”

“… Cambogin, flavonoids, HCA (-hydroxy citric acid), polyphenols, and garcinol are bioactive ingredients ( Bhattacharjee and Devi, 2021 ). Traditional claims and beliefs about its anti-diabetic properties, molecular mechanism, and pharmacological mode of action are not clear over time ( Bhattacharjee and Devi, 2021 ). 10 Gymnema sylvestre (Retz.)…”

Nutritional evaluation and GC–MS analysis of bioactive compounds present in methanol extracts of dried fruit pericarp of garcinia pedunculata Roxb

“…Hydroxycitric acid emerged as the predominant organic acid, accompanied by hydroxycitric acid lactone, ascorbic acid and oxalic acid (Jayaprakasha et al, 2003) (Jayaprakasha et al, 2003;Rao et al, 1974;Sahu et al, 1989;Vo et al, 2012). A comprehensive chemical profiling of this species remains an ongoing endeavor despite these findings (Bhattacharjee & Devi, 2021).…”

Influence of Drying Condition on Nutritional and Chemical Profile of Garcinia pedunculata Roxb. Fruit

“…It is an endemic medicinal plant of India’s North-Eastern Region (NER) and belongs to the Clusiaceae family. 14 It is an evergreen tree bearing an edible, highly acidic, globose fruit that has enormous medicinal properties and is widely used in culinary applications. 15, 16 As per the ethnomedicinal practices of NER, the juice prepared from the dried pulps of G. pedunculata (GP) fruits has immense therapeutic importance in treating gastrointestinal disorders such as jaundice, indigestion, dysentery, and diarrhoea.…”