A Comprehensive Review of Genistein’s Effects in Preclinical Models of Cervical Cancer

Abstract

Cervical cancer is associated with persistent Human Papilloma Virus (HPV) infections and is the fourth most common cancer in women worldwide. Current treatment options; surgery, chemotherapy, and radiation, are often associated with severe side effects including possible infertility. Novel treatment options are required to help combat this disease and reduce side effects. Many plant-derived chemicals, including paclitaxel and docetaxel, are already in use as treatments for various cancers. Genistein is a polyphenolic isoflavone found in foods including soybeans and legumes, and studies have shown that it has various biological effects and anti-cancer properties. This review aims to summarize the existing studies examining the effects of genistein on cervical cancer. All relevant in vitro and in vivo studies are summarized, and the key findings are highlighted in the associated tables. Based on the available in vitro/cell culture studies reported here, genistein inhibits cervical cancer cell proliferation and induces apoptosis. Use of genistein in combination with radiation or chemotherapy agents resulted in enhanced response indicating radio- and chemo-sensitization properties. More animal studies are required to examine the effectiveness of genistein in vivo. Such studies will form the basis for future human studies exploring the potential of genistein to be used in the treatment of cervical cancer.

Molecular Pathways of Genistein Activity in Breast Cancer Cells

“…Several studies supporting the multi-target mechanism of genistein's anti-tumor activities have been conducted [66][67][68][69][70][71][72][73][74]. Cell cycle regulation [75,76], tyrosine kinases [77], DNA topoisomerases [78], telomerase [79], apoptosis [80], and angiogenesis [81] have all been found to be inhibited by genistein.…”