In honor of its 50th anniversary, the World Futures Studies Federation (WFSF) held its XXV World Conference in Paris. The conference provided a venue for reviewing earlier developments and reevaluating prospective directions in the futures field. Scientific-based futures studies has a long history, drawing from a variety of fields including sociology, policy sciences, philosophy of science, economic prognostics, and environmental sustainability. Futures studies became widely acknowledged as an academic discipline in the 1960s when it became evident in the global scientific community. The 1970s saw a focus on global challenges and discussions about preferred futures. The synthesis of futures studies emerged in the 1980s and 1990s, with critical and evolutionary approaches contributing to the advancement of theoretical foundations. The twenty-first century focuses on anticipation and futures literacy, the development of post-normal, metamodern, and integral approaches, and the attainment of foresight in common practice. Future research is expected to focus on various aspects, including artificial general intelligence (AGI), socio-technical transitions, singularity, sustainability, societal collapses, entrepreneurial innovation, energy futures, decolonization, negation and post-prefix notions, systemic foresight, applied foresight, and on-site foresight. Future research activities are expected to also include research objects, policy challenges, and problems that do not yet exist.