2017
DOI: 10.1016/j.taap.2017.05.004
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A comprehensive review of metal-induced cellular transformation studies

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Cited by 26 publications
(28 citation statements)
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“…Exposure to arsenic has been shown to induce malignant transformation, and a number of studies have demonstrated its ability to transform human bronchial epithelial cells. 51 While the amount of time and concentration required for malignant transformation may differ by cell type, 52 here we report that 6 weeks of 2 μM arsenic exposure was sufficient to induce anchorage-independent growth in BEAS-2B cells ( Figure 1A). Of note, two micromolar of arsenic is equivalent to 150 ppb, which are similar to levels found in the environment.…”
Section: Arsenic Exposure Promotes Anchorageindependent Growth Migmentioning
confidence: 59%
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“…Exposure to arsenic has been shown to induce malignant transformation, and a number of studies have demonstrated its ability to transform human bronchial epithelial cells. 51 While the amount of time and concentration required for malignant transformation may differ by cell type, 52 here we report that 6 weeks of 2 μM arsenic exposure was sufficient to induce anchorage-independent growth in BEAS-2B cells ( Figure 1A). Of note, two micromolar of arsenic is equivalent to 150 ppb, which are similar to levels found in the environment.…”
Section: Arsenic Exposure Promotes Anchorageindependent Growth Migmentioning
confidence: 59%
“…Of the currently available 17 studies, five have suggested that miR‐31 was an upstream negative regulator of SATB2 . Furthermore, of the seven known miR‐31 targets, SATB2 was by far the most frequently identified . Physically, miR‐31 was capable of binding to two sites in the SATB2 3′‐UTR region; Figure A demonstrates the sequences that bind with miR‐31 (miRmap: http://mirmap.ezlab.org/).…”
Section: Resultsmentioning
confidence: 99%
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“…Arsenic is one of the most well-known human carcinogens, and long-term exposure can significantly increase the risk of developing multiple type of cancers including lung, skin, kidney, liver and bladder cancer 3,21 . It is generally accepted that epigenetic mechanism may play a key role in arenic-induced tumorigenesis mostly due to its weakly genotoxic carcinogen 22,23 .…”
Section: Discussionmentioning
confidence: 99%
“…Chronic exposure to inorganic arsenic has been associated with numerous adverse health outcomes, including lung, skin, kidney, liver, prostate and urinary bladder cancers, skin lesions and cardiovascular disease 2 . Arsenic can induce immortalized human cell line such as BEAS-2B to become malignant transformed cells, which possess the intrinsic properties of cancer cells such as loss of contact inhibition, gain of anchorage-independent growth, resistant to apoptosis, enhance of cellular migration and invasion, and the ability of tumor formation on xenograft mouse model 3 . Several genotoxic and epigenetic alterations have been tightly associated with the arsenic transformation process, which leads to increased cancer risk.…”
Section: Introductionmentioning
confidence: 99%