A Comprehensive Review of Microneedling as a Potential Treatment Option for Androgenetic Alopecia

Jia, Lingling; Xiong, Jiachao; Guo, Rong; Li, Yufei; Jiang, Hua

doi:10.1007/s00266-022-03042-y

Cited by 8 publications

(4 citation statements)

References 68 publications

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“…Equally vital is low-level laser therapy (LLLT) that stimulates mitochondria in hair stem cells, increasing reactive oxygen species (ROS) and adenosine triphosphate (ATP) to enhance cell proliferation and migration, promoting hair growth [ 66 , 67 ]. Microneedling, an emerging medical technology extensively used in transdermal drug delivery, is also increasingly applied in AGA treatment [ [68] , [69] , [70] ].…”

Section: Resultsmentioning

confidence: 99%

Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy

Xing,

Peng,

Yang

et al. 2024

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy

Xing,

Peng,

Yang

et al. 2024

Bioactive Materials

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“…It involves the use of a handheld device with tiny needles to create channels on the scalp, stimulating collagen production and enhancing the absorption of topical medications. 38 Previous studies have demonstrated the combined effect of microneedle therapy with other hair loss treatments. For example, patients with androgenetic alopecia who received a combination of low-level laser and microneedle therapy showed increased hair density.…”

Section: Discussionmentioning

confidence: 99%

Hair regeneration using microneedle-assisted human basic fibroblast growth factor

Xin,

Hei,

Lai

et al. 2023

JAPLR

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Hair loss has afflicted numerous patients for several decades. However, the current drug treatment is only effective for specific types of alopecia and their efficacy is limited. Additionally, the cost of hair transplant surgery is relatively high, making it unaffordable for some patients. In this study, we propose a new treatment method using microneedles and growth factors to alleviate alopecia. The results of our study demonstrate that patients receiving human basic fibroblast growth factor (hbFGF) therapy experienced significant hair regeneration. Both male and female patients responded positively to the growth factor treatment, with males showing better results. Importantly, microneedle-assisted hbFGF therapy can be universally applied to androgenetic alopecia, alopecia areata, and telogen effluvium. In summary, this study presents a novel and highly effective method that shows great potential for treating alopecia, with high levels of safety and efficacy.

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“…The use of MN patches for hair loss treatment also provides the additional benefit of the mechanical stimulation of the skin, with the effect having already been demonstrated in other research. 8,45 Although another study recently reported their design of dissolving MN patches for the controlled release of MXD that used a mesoporous iron oxide nanoraspberry to encapsulate MXD and achieved the controlled release of the drug by applying an external magnetic field, 27 this MN-based system did not support the long-term release of MXD and was limited by the multiple application times of the magnetic stimulus, as well as by the uncertain biocompatibility and biosafety of the materials used in MN patches.…”

Section: Long-acting Therapeutic Efficacy Of Mxd Mn Patchesmentioning

confidence: 99%

Dissolving Microneedle Patch Integrated with Microspheres for Long-Acting Hair Regrowth Therapy

Yin

Zeng

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Androgenetic alopecia (AGA) is the most common type of progressive hair loss in both men and women that severely reduces life quality and affects patients’ self-esteem. Due to the shortcomings of traditional therapeutic formulations (e.g., topical minoxidil and oral finasteride), such as low bioavailability, frequent dosing, and significant side effects, there is an urgent need to develop a safe and effective strategy for AGA treatment. Here, we report a water-soluble microneedle (MN) patch integrated with biodegradable minoxidil (MXD)-loaded microspheres for long-acting AGA treatment with reduced administration frequency and improved patient compliance. When the patch pierces the skin, the MNs rapidly dissolve and deliver MXD-encapsulated polylactic-co-glycolic acid (PLGA) microspheres into the skin, which, subsequently act as drug reservoirs for the sustained release of the therapeutics for over 2 weeks. Additionally, the application of the MN patch provided a mechanical stimulation on mouse skin, which was also helpful for hair regrowth. Compared with the topical MXD solutions that have been commercialized on the market and require daily application, the long-acting MN patch contains a much lower drug amount and shows a similar or superior hair regeneration effect in AGA mice while only requiring monthly or weekly administration. These encouraging results suggest a simple, safe, and effective strategy for long-acting hair regeneration in clinics.

show abstract

A Comprehensive Review of Microneedling as a Potential Treatment Option for Androgenetic Alopecia

Cited by 8 publications

References 68 publications

Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy

Nitric oxide synergizes minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy

Hair regeneration using microneedle-assisted human basic fibroblast growth factor

Dissolving Microneedle Patch Integrated with Microspheres for Long-Acting Hair Regrowth Therapy

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