A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds

Wu, Shengjun; Pang, Yaobin; He, Yun; Zhang, Xiaolin; Peng, Li; Guo, Jun; Zeng, Jinhao

doi:10.1016/j.biopha.2021.111741

Cited by 80 publications

(54 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, the use of natural products was considered very reliable in the treatment of diseases caused by immune inflammation of the skin. 57 Based on previous studies, we hypothesized that OST is a promising therapeutic agent for inflammatory skin diseases caused by bacterial infections and by sudden histamine release due to contact allergies.…”

Section: Discussionmentioning

confidence: 99%

Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-κB in Normal Human Keratinocytes and Fibroblasts

Kordulewska

Topa

Cieślińska

et al. 2022

JIR

View full text Add to dashboard Cite

Introduction Osthole (OST), an active compound isolated from Cnidium monnieri , is used in traditional Chinese medicine to treat a variety of human diseases. Although OST has a good therapeutic effect, the underlying mechanism of its action in inflammatory skin diseases in humans is still unknown. Purpose The present study aimed to test the hypothesis that OST can be used as an herbal substance that minimizes skin inflammation and barrier dysfunction. In this study, histamine and LPS were used to induce inflammation in skin keratinocytes and fibroblasts to test whether OST can inhibit their responses. Methods Cell migration was analyzed using a wound healing assay. Changes in cell monolayer integrity were assessed by the measurement of transepithelial electrical resistance. Secretion of IL-1β, IL-6, IL-8, TNF-α, CCL2/MCP-1, CCL5/RANTES, and COX-2 was measured by ELISA, while expression of TLR2, NF-κB , and COX -2 was analyzed by qPCR. Results OST decreased the level of IL-1β, TNF-α, CCL2/MCP-1 and CCL5/RANTES, and expression of TLR2, NF-κB and COX-2 during histamine/LPS-induced inflammation in human keratinocytes and fibroblasts. OST also improved cell migration and cell barrier function. Conclusion Our results suggest that OST suppresses inflammatory responses via regulation of IL-1β, TNF-α, CCL2/MCP-1 and CCL5/RANTES secretion, and TLR2 , and COX-2 expression.

show abstract

Section: Discussionmentioning

confidence: 99%

Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-κB in Normal Human Keratinocytes and Fibroblasts

Kordulewska

Topa

Cieślińska

et al. 2022

JIR

View full text Add to dashboard Cite

show abstract

“…These findings also suggest that local inhibition of the production of cytokines involved in dermal sensitization, such as TARC and TSLP, and allergic responses in the skin may be related to the inhibition of transdermal sensitization by TA. Indeed, it has been reported that TAs and quercetin may be therapeutically effective in AD by suppressing the expression of Th2 related cytokines, including TSLP and TARC, in Nc/Nga murine models showing pathologies such as AD [ 19 , 20 ]. In addition, mite-induced AD may be induced via NF-κB signaling, and some reports indicate that TA may inhibit its signaling and inflammation [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Co-Application with Tannic Acid Prevents Transdermal Sensitization to Ovalbumin in Mice

Izumi

Tanahashi

Kinugasa

et al. 2022

IJMS

View full text Add to dashboard Cite

Transdermal sensitization to allergens is of great concern as a sensitization route for food allergies. This skin-mediated invasion and sensitization to allergens is involved in skin barrier breakdown and inflammation, followed by the production of several kinds of cytokines. Cytokines such as thymic stromal lymphopoietin and thymus and activation-regulated chemokine are also involved. In this study, we investigated the suppressive effect of tannic acid (TA) on transdermal sensitization using ovalbumin (OVA), a major egg-white allergen. We also analyzed the mechanisms associated with the inhibitory effects of TA. The results showed that the co-application with TA prevents transdermal sensitization to OVA. As possible mechanisms, its anti-inflammatory and astringent effect on the skin and binding ability with the protein were considered. These results indicate that TA could be applied to cosmetics and lotions, which could suppress the transdermal sensitization to allergens.

show abstract

“…Skin barrier dysfunction increases the penetration of allergens and pathogens, leading to immune alteration and further disruption of the barrier function [38,39]. The secondary lymphoid tissues including the spleen and lymph nodes are the main regions exposed to various allergens in the chronic stage of AD, which further differentiates naïve T cells into effector T cells, and stimulates B cells to produce IgE [18,40]. Our DNCB-induced AD-like model showed the hypertrophic changes of the spleen and lymph node with the increased inflammatory cytokines in previous and current studies [26].…”

Section: Discussionmentioning

confidence: 99%

“…Here, fRGM improved antioxidant capacities in AD-like skin lesions by increasing antioxidants (GSH) and by reducing lipid peroxidation (MDA and 4-HNE) and superoxide anion, and RONS-induced protein nitration (NT). Natural products generally possess polyphenolic compounds and flavonoids that act as direct free radical scavengers against superoxide anions and inhibitors of lipid peroxidation [18]. Indeed, fRGM contained the polyphenolic compounds and flavonoids despite the small contents, and the antioxidant activities could be enhanced via fermentation with effective microorganisms [22,23,43].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies also support the anti-AD effects by showing improved clinical symptoms following the reduction in serum IgE levels [15,16]. In particular, ginsenosides including Rb1, Rb2, Rg3 and Rh1 amongst compounds belonging to red ginseng, are believed to be responsible for the anti-AD effects via immune-modulating and anti-inflammatory pathways [2,17,18].…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model

Jung¹,

Choi²,

Park³

et al. 2022

Preprint

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic and allergic skin disease, however, there is no cure for the disease. Many studies have shown anti-AD potentials of red ginseng, while red ginseng marc (RGM) remained after the ginseng extraction is discarded as industrial waste. However, it is recently reported that RGM, particularly fermented RGM (fRGM), still contains the bioactive properties. Thus, anti-allergic effects of fRGM were examined in 2,4-dinitrochlorobenzene-induced AD-like mice model. The model was topically treated with distilled water (control), dexamethasone, or fRGM for six weeks. The treatments of fRGM alleviated the skin lesions and reduced serum IgE levels, compared with the control. The fRGM also reduced skin levels of lipid peroxidation and superoxide anion, however, increased glutathione contents, with down-regulated gene expressions for inflammatory mediators. The histopathological analyses demonstrated that fRGM suppressed the epidermal thickening, collagen deposition, and inflammatory cell and mast cell infiltration, which involved the anti-inflammatory, anti-oxidant, and anti-apoptotic effects. Further, fRGM suppressed hypertrophic changes and inflammatory responses in the spleen and lymph node. The beneficial effects were observed in the dexamethasone and fRGM groups, however, the antioxidant effects were evident only in the fRGM treatments. These provide useful information for developing fRGM as therapeutic sources for AD.

show abstract

A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds

Cited by 80 publications

References 146 publications

Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-κB in Normal Human Keratinocytes and Fibroblasts

Osthole Regulates Secretion of Pro-Inflammatory Cytokines and Expression of TLR2 and NF-κB in Normal Human Keratinocytes and Fibroblasts

Co-Application with Tannic Acid Prevents Transdermal Sensitization to Ovalbumin in Mice

Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model

Contact Info

Product

Resources

About