A Comprehensive Review of Sulfonamide Hypersensitivity: Implications for Clinical Practice

Serrano-Arias, Bruno; Araya-Zúñiga, Adriana; Waterhouse-Garbanzo, Johan; Rojas-Barrantes, Zoe; Arguedas-Chacón, Sebastián; Zavaleta-Monestel, Esteban

doi:10.1007/s12016-023-08978-w

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…In this case, antibiotic replacement is the best option. Sulfonamides should only be administered when there is no other acceptable and effective treatment available [ 101 ].…”

Section: Antibiotics For Which the Role Of Genetics In Conditioning D...mentioning

confidence: 99%

Genetic Variations and Antibiotic-Related Adverse Events

Principi,

Petropulacos,

Esposito

2024

Pharmaceuticals

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Antibiotic-related adverse events are common in both adults and children, and knowledge of the factors that favor the development of antibiotic-related adverse events is essential to limit their occurrence and severity. Genetics can condition the development of antibiotic-related adverse events, and the screening of patients with supposed or demonstrated specific genetic mutations may reduce drug-related adverse events. This narrative review discusses which genetic variations may influence the risk of antibiotic-related adverse events and which conclusions can be applied to clinical practice. An analysis of the literature showed that defined associations between genetic variations and specific adverse events are very few and that, at the moment, none of them have led to the implementation of a systematic screening process for patients that must be treated with a given antibiotic in order to select those at risk of specific adverse events. On the other hand, in most of the cases, more than one variation is implicated in the determination of adverse events, and this can be a limitation in planning a systematic screening. Moreover, presently, the methods used to establish whether a patient carries a “dangerous” genetic mutation require too much time and waiting for the result of the test can be deleterious for those patients urgently requiring therapy. Further studies are needed to definitively confirm which genetic variations are responsible for an increased risk of a well-defined adverse event.

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“…In this case, antibiotic replacement is the best option. Sulfonamides should only be administered when there is no other acceptable and effective treatment available [ 101 ].…”

Section: Antibiotics For Which the Role Of Genetics In Conditioning D...mentioning

confidence: 99%

Genetic Variations and Antibiotic-Related Adverse Events

Principi,

Petropulacos,

Esposito

2024

Pharmaceuticals

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“…Since then, they have been widely used for their antibacterial qualities, especially in fighting bacterial infections. In addition to their antibacterial properties, sulfonamide drugs also demonstrate effectiveness against specific protozoal infections, making them highly flexible in the treatment of infectious diseases.Sulfonamide drugs have become a vital class of substances with a wide range of therapeutic uses in the field of pharmaceutical research 2 . Sulfonamide’s drugs are also commonly used for the treatment of urinary tract infections, respiratory tract infections, and bacterial meningitis 3 .…”

Section: Introductionmentioning

confidence: 99%

A python based algorithmic approach to optimize sulfonamide drugs via mathematical modeling

Ahmed,

Ali,

Zaman

et al. 2024

Sci Rep

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This article explores the structural properties of eleven distinct chemical graphs that represent sulfonamide drugs using topological indices by developing python algorithm. To find significant relationships between the topological characteristics of these networks and the characteristics of the associated sulfonamide drugs. We use quantitative structure-property relationship (QSPR) approaches. In order to model and forecast these correlations and provide insights into the structure-activity relationships that are essential for drug design and optimization, linear regression is a vital tool. A thorough framework for comprehending the molecular characteristics and behavior of sulfonamide drugs is provided by the combination of topological indices, graph theory and statistical models which advances the field of pharmaceutical research and development.

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