A comprehensive review of surgical margin in oral squamous cell carcinoma highlighting the significance of tumor-free surgical margins

Kamat, Mamata; Das, Bhagawan; Puranik, Rudrayya S; Datar, Uma Vasant

doi:10.4103/jcrt.jcrt_273_17

Cited by 36 publications

(33 citation statements)

References 31 publications

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“…For resectable tumors, surgery is superior to all other therapies, but for surgical resection, sufficient margins for the primary tumor must be available. Failure to obtain a clear surgical margin leads to an increased risk of local recurrence and subsequently a poor prognosis [127].…”

Section: Surgical Resectionmentioning

confidence: 99%

The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence

Lee

Tseng

2020

Biomolecules

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The etiological factors of oral cancer are complex including drinking alcohol, smoking tobacco, betel quid chewing, human papillomavirus infection, and nutritional deficiencies. Understanding the molecular mechanism of oral cancer is vital. The traditional treatment for patients with oral squamous cell carcinoma (e.g., surgery, radiotherapy, and chemotherapy) and targeted molecular therapy still have numerous shortcomings. In recent years, the use of phytochemical factors to prevent or treat cancer has received increasing attention. These phytochemicals have little or no toxicity against healthy tissues and are thus ideal chemopreventive agents. However, phytochemicals usually have low water solubility, low bioavailability, and insufficient targeting which limit therapeutic use. Numerous studies have investigated the development of phytochemical delivery systems to address these problems. The present article provides an overview of oral cancer including the etiological factors, diagnosis, and traditional therapy. Furthermore, the classification, dietary sources, anticancer bioactivity, delivery system improvements, and molecular mechanisms against oral cancer of phytochemicals are also discussed in this review.

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Section: Surgical Resectionmentioning

confidence: 99%

The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence

Lee

Tseng

2020

Biomolecules

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“…Surgery remains the primary treatment option for most solid malignant tumors [1]. Precise and complete resection of the whole tumor without unnecessary removal of the neighboring healthy tissue is a prerequisite for a successful outcome [2]. Unfortunately, visual distinction between the malignant and healthy tissue using only the surgeon's naked eye is often almost impossible.…”

Section: Introductionmentioning

confidence: 99%

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors

et al. 2020

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This report describes the design, synthesis and evaluation of tumor-targeted polymer probes to visualize epidermal growth factor receptor (EGFR)-positive malignant tumors for successful resection via fluorescence guided endoscopic surgery. Fluorescent polymer probes of various molecular weights enabling passive accumulation in tumors via enhanced permeability and retention were prepared and evaluated, showing an optimal molecular weight of 200,000 g/mol for passive tumor targeting. Moreover, poly(N-(2-hydroxypropyl)methacrylamide)-based copolymers labeled with fluorescent dyes were targeted with the EGFR-binding oligopeptide GE-11 (YHWYGYTPQNVI), human EGF or anti-EGFR monoclonal antibody cetuximab were all able to actively target the surface of EGFR-positive tumor cells. Nanoprobes targeted with GE-11 and cetuximab showed the best targeting profile but differed in their tumor accumulation kinetics. Cetuximab increased tumor accumulation after 15 min, whereas GE 11 needed at least 4 h. Interestingly, after 4 h, there were no significant differences in tumor targeting, indicating the potential of oligopeptide targeting for fluorescence-navigated surgery. In conclusion, fluorescent polymer probes targeted by oligopeptide GE-11 or whole antibody are excellent tools for surgical navigation during oncological surgery of head and neck squamous cell carcinoma, due to their relatively simple design, synthesis and cost, as well as optimal pharmacokinetics and accumulation in tumors.

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“…About 300,000 new cases are estimated to be diagnosed annually worldwide, and locoregional recurrences may occur in 30-35% of patients, 20% of whom die of OSCC eventually [3,4]. The high recurrence and metastasis rate of OSCC lead to the 5-year survival rate of less than 50% [5,6]. In recent years, treatment options, particularly for advanced (III and IV) malignancies, have been surgery, radiation and/or chemotherapy and targeted therapy, including cisplatin (CDDP), docetaxel (DTX), 5-Fluorouracil (5-FU) and cetuximab [1,7].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Circulating Natural Autoantibodies to CD47-derived Peptides on Oral Squamous Cell Carcinoma Cells

Liu

Meng

et al. 2020

Preprint

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Background Natural autoantibodies serve as an important anti-tumorigenic system due to its immune surveillance function. The present study aims to investigate whether circulating natural IgG autoantibodies against cluster of differentiation 47 (CD47) could inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells. Methods The expression of 14 tumor-targeted genes in three OSCC cell lines was analyzed with quantitative real-time PCR. The in-house enzyme-linked immunosorbent assay (ELISA) was then performed to detect plasma IgG antibodies against CD47. Three OSCC cell lines were treated with 20% human plasma positive and negative for anti-CD47 IgG, respectively, followed by analysis of cell proliferation, apoptosis and invasion/metastasis. Results CD 47 showed highest expression among all 14 genes detected in three OSCC cell lines. Plasma anti-CD47 IgG significantly inhibited the viability of all three OSCC cell lines. The proportions of apoptotic cells were remarkably higher in OSCC cells treated with anti-CD47 IgG-positive plasma than those treated with IgG-negative plasma. Furthermore, the cell invasion/metastasis was attenuated evidently with the attribution of plasma anti-CD47 IgG. Conclusions Natural autoantibodies against CD47 may be a potential target for OSCC immunotherapy.

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A comprehensive review of surgical margin in oral squamous cell carcinoma highlighting the significance of tumor-free surgical margins

Cited by 36 publications

References 31 publications

The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence

The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors

Inhibitory Effects of Circulating Natural Autoantibodies to CD47-derived Peptides on Oral Squamous Cell Carcinoma Cells

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