A comprehensive review of the physicochemical, quality and nutritional properties of <i>Nigella sativa</i> oil

Mazaheri, Yeganeh; Torbati, Mohammadali; Azadmard‐Damirchi, Sodeif; Savage, Geoffrey P.

doi:10.1080/87559129.2018.1563793

Cited by 69 publications

(50 citation statements)

References 72 publications

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“…The aqueous and oil extracts of the seeds have been shown to possess antioxidant, anti-inflammatory, anticancer, analgesic, and antibacterial activities. [39,40] The NS was loaded in nanofiber scaffolds for applications tissue engineering and drug delivery. Recently, many researchers investigated the incorporation of NS oil in different polymer matrices for biological applications.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Sharifi

Bahrami

Nejad

et al. 2020

J of Applied Polymer Sci

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Black seed (Nigella sativa [NS]) is used in traditional medicine as an antibacterial agent. In this study, novel hybrid scaffolds were manufactured from poly(ɛ‐caprolactone[PCL])/ Poly(lactic acid [PLA]) with NS extract by double‐nozzle electrospinning for wound healing application. Optimal conditions were found using response surface methodology including feed rate 0.8 ml/hr, voltage 20 kV and PLA 8% /PCL 10% concentrations. The effect of NS extract on the properties of the scaffold was evaluated by scanning electron microscopy, contact angle, and mechanical test. The PLA‐PCL/NS 20% beadles, and smooth nanofibrous web was obtained as the optimum scaffold with an average diameter of 638 ± 69 nm and the contact angle of 44°. In addition, the biological properties of the scaffolds such as antibacterial against Staphylococcus aureus (gram‐positive) and Escherichia coli (gram‐negative) bacteria, MTT assay, extract release, and cell growth (human mesenchymal stem cells) were examined. Incorporation of NS extract into the nanofibers caused to enhance the biological properties, cell viability and cell proliferation without toxicity.

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Section: Introductionmentioning

confidence: 99%

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Sharifi

Bahrami

Nejad

et al. 2020

J of Applied Polymer Sci

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“…In addition, the seeds contain active phytochemicals, such as thymoquinone, thymohydroquinone, q-cymene, carvacrol, and 4-terpineol [5]. This oil can be used as a natural resource for the production of pharmaceuticals and novel functional foods thanks to its composition and effects [2,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Caseinate-Stabilized Emulsions of Black Cumin and Tamanu Oils: Preparation, Characterization and Antibacterial Activity

et al. 2019

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Caseinate-stabilized emulsions of black cumin (Nigella sativa) and tamanu (Calophyllum inophyllum) oils were studied in terms of preparation, characterization, and antibacterial properties. The oils were described while using their basic characteristics, including fatty acid composition and scavenging activity. The oil-in-water (o/w) emulsions containing the studied oils were formulated, and the influence of protein stabilizer (sodium caseinate (CAS), 1–12 wt%), oil contents (5–30 wt%), and emulsification methods (high-shear homogenization vs sonication) on the emulsion properties were investigated. It was observed that, under both preparation methods, emulsions of small, initial droplet sizes were predominantly formed with CAS content that was higher than 7.5 wt%. Sonication was a more efficient emulsification procedure and was afforded emulsions with smaller droplet size throughout the entire used concentration ranges of oils and CAS when compared to high-shear homogenization. At native pH of ~ 6.5, all of the emulsions exhibited negative zeta potential that originated from the presence of caseinate. The antibacterial activities of both oils and their emulsions were investigated with respect to the growth suppression of common spoilage bacteria while using the disk diffusion method. The oils and selected emulsions were proven to act against gram positive strains, mainly against Staphylococcus aureus (S. aureus) and Bacillus cereus (B. cereus); regrettably, the gram negative species were fully resistant against their action.

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“…methylbenzo-1,4-quinone, is a quinone with relatively poor water solubility (0.549-0.740 g/L) [8,9]. Among its pharmacological properties, TQ displays antioxidant, antihistamine, immunomodulatory, anti-inflammatory, anti-microbial, and neuroprotective activities [2,[5][6][7]10,11]. It was also reported that TQ is a potent anticancer agent and has potential in the prevention and treatment of breast, colon, and ovarian cancers [4,9,10,[12][13][14].…”

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confidence: 99%

Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

2019

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Owing to their unique structural features, non-lamellar liquid crystalline nanoparticles comprising cubosomes and hexosomes are attracting increasing attention as versatile investigative drug carriers. Background: Depending on their physiochemical characteristics, drug molecules on entrapment can modulate and reorganize structural features of cubosomes and hexosomes. Therefore, it is important to assess the effect of guest molecules on broader biophysical characteristics of non-lamellar liquid crystalline nanoparticles, since drug-induced architectural, morphological, and size modifications can affect the biological performance of cubosomes and hexosomes. Methods: We report on alterations in morphological, structural, and size characteristics of nanodispersions composed from binary mixtures of glycerol monooleate and vitamin E on thymoquinone (a molecule with wide therapeutic potentials) loading. Results: Thymoquinone loading was associated with a slight increase in the mean hydrodynamic nanoparticle size and led to structural transitions from an internal biphasic feature of coexisting inverse cubic Fd3m and hexagonal (H2) phases to an internal inverse cubic Fd3m phase (micellar cubosomes) or an internal inverse micellar (L2) phase (emulsified microemulsions, EMEs). We further report on the presence of “flower-like” vesicular populations in both native and drug-loaded nanodispersions. Conclusions: These nanodispersions have the potential to accommodate thymoquinone and may be considered as promising platforms for the development of thymoquinone nanomedicines.

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A comprehensive review of the physicochemical, quality and nutritional properties of Nigella sativa oil

Cited by 69 publications

References 72 publications

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Caseinate-Stabilized Emulsions of Black Cumin and Tamanu Oils: Preparation, Characterization and Antibacterial Activity

Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

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