2023
DOI: 10.7759/cureus.47525
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A Comprehensive Review of the Vascular Consequences of Diabetes in the Lower Extremities: Current Approaches to Management and Evaluation of Clinical Outcomes

Akanksha Yachmaneni,
Suhas Jajoo,
Chandrashekhar Mahakalkar
et al.

Abstract: Diabetes mellitus is a global health concern characterized by chronic hyperglycemia, and its vascular consequences in the lower extremities pose significant challenges for individuals living with the condition. This comprehensive review delves into the multifaceted landscape of diabetes-related vascular complications in the lower limbs, with a primary focus on current strategies for management and the evaluation of clinical outcomes. This review achieves several critical objectives by synthesizing existing kno… Show more

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Cited by 6 publications
(2 citation statements)
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“…In addition, many patient comorbidities can lead to delayed donor site healing and prolonged hospitalization. [3][4][5][6] The Autologous Cell Harvesting Device (ACHD; RECELL ® Autologous Cell Harvesting Device, AVITA Medical, Inc) was developed to maximize skin utilization and promote healing by delivery of cells primed for epidermal regeneration. 7 The device enables a clinician to process a small split-thickness piece of skin into individual keratinocytes, fibroblasts and melanocytes at the point-of-care.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition, many patient comorbidities can lead to delayed donor site healing and prolonged hospitalization. [3][4][5][6] The Autologous Cell Harvesting Device (ACHD; RECELL ® Autologous Cell Harvesting Device, AVITA Medical, Inc) was developed to maximize skin utilization and promote healing by delivery of cells primed for epidermal regeneration. 7 The device enables a clinician to process a small split-thickness piece of skin into individual keratinocytes, fibroblasts and melanocytes at the point-of-care.…”
Section: Introductionmentioning
confidence: 99%
“…Although effective, autografting necessitates donor site wounds which frequently are more troublesome for patients than the primary injury, as they are a source of significant pain and are at risk for infection, discoloration and scarring. In addition, many patient comorbidities can lead to delayed donor site healing and prolonged hospitalization 3–6 …”
Section: Introductionmentioning
confidence: 99%