A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia

Ovrom, Erik; Mostert, Karson A.; Khakhkhar, Shivani; McKee, Daniel P.; Yang, Padao; Her, Yeng F.

doi:10.3390/biomedicines11041119

Cited by 8 publications

(6 citation statements)

References 146 publications

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“…Vegetarian diets have been associated with improvements in biomarkers related to oxidative stress and inflammation [ 35 ], which are the mechanisms involved in the complex pathophysiology of FM [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Restrictive Diets in Patients with Fibromyalgia: State of the Art

Almirall,

Musté,

Serrat

et al. 2024

Biomedicines

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Around 20–30% of Fibromyalgia patients modify their dietary habits after diagnosis, including avoiding certain food groups such as cereals. In this systematic review, we used the PRISMA guidelines to select the main studies that have evaluated the effectiveness of restrictive diets, including elimination and vegetarian diets, in patients with Fibromyalgia. Data on vegetarian/vegan diets are more consistent than data on elimination diets due to higher quality and better results of the published studies. Although the results are favorable in most of the studies, their heterogenicity and the scarce and low quality of the evidence (small number of patients included, often non-randomized and uncontrolled studies and multiple confounding factors and biases) does not allow for a positive recommendation about these restrictive diets in Fibromyalgia patients. Several factors other than food restriction could influence the symptomatic and functional improvements observed after restrictive diets, such as the placebo effect, weight loss that often occurs, coexistence with gastrointestinal diseases and positive effects of unrestricted foods. We must advance more and improve in our knowledge of the effectiveness of restrictive diets and variables related to them before recommending them systematically to all patients with Fibromyalgia. Randomized, placebo-controlled trials with large sample sizes, longer follow-up periods and standardized outcome measures that explore predictors of dietary response are needed to better understand the relationship between Fibromyalgia and nutrition.

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Section: Resultsmentioning

confidence: 99%

Restrictive Diets in Patients with Fibromyalgia: State of the Art

Almirall,

Musté,

Serrat

et al. 2024

Biomedicines

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show abstract

“…Moreover, various environmental triggers, including infectious agents, toxins, and physical or emotional stressors, have been proposed as potential triggers that can induce or exacerbate mitochondrial dysfunction in susceptible individuals. These triggers may lead to mitochondrial damage, oxidative stress, and inflammation, further impairing mitochondrial function and perpetuating the cycle of fatigue and other core symptoms in people with PVFS [ 50 , 51 , 52 , 53 , 54 , 55 ].…”

Section: Evidence Of Mitochondrial Dysfunction In Post-viral Fatigue ...mentioning

confidence: 99%

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

Mantle,

Hargreaves,

Domingo

et al. 2024

IJMS

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Post-viral fatigue syndrome (PVFS) encompasses a wide range of complex neuroimmune disorders of unknown causes characterised by disabling post-exertional fatigue, myalgia and joint pain, cognitive impairments, unrefreshing sleep, autonomic dysfunction, and neuropsychiatric symptoms. It includes myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS); fibromyalgia (FM); and more recently post-COVID-19 condition (long COVID). To date, there are no definitive clinical case criteria and no FDA-approved pharmacological therapies for PVFS. Given the current lack of effective treatments, there is a need to develop novel therapeutic strategies for these disorders. Mitochondria, the cellular organelles responsible for tissue energy production, have recently garnered attention in research into PVFS due to their crucial role in cellular bioenergetic metabolism in these conditions. The accumulating literature has identified a link between mitochondrial dysfunction and low-grade systemic inflammation in ME/CFS, FM, and long COVID. To address this issue, this article aims to critically review the evidence relating to mitochondrial dysfunction in the pathogenesis of these disorders; in particular, it aims to evaluate the effectiveness of coenzyme Q10 supplementation on chronic fatigue and pain symptoms as a novel therapeutic strategy for the treatment of PVFS.

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“…Despite extensive research, the exact cause of fibromyalgia remains unknown, and there are several theories that have been proposed to explain its underlying mechanisms [ 2 , 3 , 4 ]; among these, the main ones are the central sensitization theory (CST) [ 5 ], the neurotransmitter imbalance theory (NIT) [ 6 ], genetic and epigenetic factors (GEF) [ 7 ], dysregulation of the immune system (DIS) [ 8 ], psychosocial and behavioral factors (PBF) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…GEF evidence suggests that genetic and epigenetic factors may play a role in the development of fibromyalgia [ 7 , 17 ]. Studies have shown that fibromyalgia tends to run in families [ 18 ], and certain gene variations have been associated with an increased risk of developing fibromyalgia [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia

Silva,

Barcessat,

Gonçalves

et al. 2023

JPM

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Fibromyalgia syndrome (FS) is a disorder characterized by widespread musculoskeletal pain and psychopathological symptoms, often associated with central pain modulation failure and dysfunctional adaptive responses to environmental stress. The Radio Electric Asymmetric Conveyer (REAC) technology is a neuromodulation technology. The aim of this study was to evaluate the effects of some REAC treatments on psychomotor responses and quality of life in 37 patients with FS. Tests were conducted before and after a single session of Neuro Postural Optimization and after a cycle of 18 sessions of Neuro Psycho Physical Optimization (NPPO), using evaluation of the functional dysmetria (FD) phenomenon, Sitting and Standing (SS), Time Up and Go (TUG) tests for motor evaluation, Fibromyalgia Impact Questionnaire (FIQ) for quality of life. The data were statistically analyzed, and the results showed a statistically significant improvement in motor response and quality of life parameters, including pain, as well as reduced FD measures in all participants. The study concludes that the neurobiological balance established by the REAC therapeutic protocols NPO and NPPO improved the dysfunctional adaptive state caused by environmental and exposomal stress in FS patients, leading to an improvement in psychomotor responses and quality of life. The findings suggest that REAC treatments could be an effective approach for FS patients, reducing the excessive use of analgesic drugs and improving daily activities.

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A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia

Cited by 8 publications

References 146 publications

Restrictive Diets in Patients with Fibromyalgia: State of the Art

Restrictive Diets in Patients with Fibromyalgia: State of the Art

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia

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