A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety

“…This ring structure is found in many naturally occurring plant-derived podophyllotoxin. The chemotherapeutic medications etoposide and teniposide are semisynthetic derivatives of podophyllotoxin, and are used as topoisomerase II inhibitor anticancer drugs [1]. Due to their high toxicity, drug resistance, and the gastrointestinal discomfort associated with their use, lots of structural modifications have been carried out; consequently, some derivatives with better performance, such as NK611, NPF, GL-331, and TOP53, have been discovered and tested in clinical trials [2].…”

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

“…Thus, topo enzymes possesses immense importance in almost all stages of the cell cycle. As a result, the role of mammalian DNA topoisomerases as molecular targets for anticancer drugs has been explored, and it was found that topoisomerase inhibition could curb cancerous cell growth across a variety of cell lines [1][2][3][4][5][6][7][8] .…”

Small DNA circles as bacterial topoisomerase I inhibitors

“…[4][5][6] For the importance of their cellular role, some topoisomerases are reported to be selected as the targets of anti-cancer drugs and antibiotics. [7][8][9] Bacterial type IIA topoisomerases, topoisomerase IV and DNA gyrase for example, are well utilized clinical targets for antibacterial chemotherapy. 10,11 However, resistance of bacterial pathogens to current antibiotics has grown to be an urgent crisis.…”