A comprehensive review on antibacterial analysis of natural extract-based metal and metal oxide nanoparticles

Shandhiya, M.; Janarthanan, B.; Sharmila, S.

doi:10.1007/s00203-023-03743-1

Cited by 6 publications

(1 citation statement)

References 154 publications

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“…Many experiments are focused on the combination of existing biomaterials with metal nanoparticles. Indeed, the antimicrobial potential of metal nanoparticles has been studied in detail by numerous researchers (e.g., [ 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 ]). Based on recent evidence, metal nanoparticles may also have an important role to play in the diagnosis and even treatment of cancer [ 270 , 271 ]; this can be important in cases of bone degeneration and even fracturing due to cancer [ 272 , 273 ].…”

Section: Discussionmentioning

confidence: 99%

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Periferakis,

Troumpata

et al. 2024

Biomimetics

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The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others. The materials discussed in the context of this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), and zirconia. While the recent research results are promising, further development is required to address the increasing antibiotic resistance exhibited by several common pathogens, the potential for fungal infections, and the potential toxicity of some metal nanoparticles. Other solutions, like the incorporation of phytochemicals, should also be explored. Incorporating artificial intelligence (AI) in the development of certain orthopedic implants and the potential use of AI against bacterial infections might represent viable solutions to these problems. Finally, there are some legal considerations associated with the use of biomaterials and the widespread use of 3D printing, which must be taken into account.

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