A comprehensive review on biocompatible Mg-based alloys as temporary orthopaedic implants: Current status, challenges, and future prospects

Bairagi, Darothi; Mandal, Sumantra

doi:10.1016/j.jma.2021.09.005

Cited by 145 publications

(57 citation statements)

References 351 publications

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“…As reported in the literature, the formation of a uniform UFG structure can improve the corrosion resistance of magnesium alloys [25][26][27][28]. In our case, the uniformity of the distribution of the Mg 41 Nd 5 particles did not cause the occurrence of inhomogeneity of corrosion, suggesting that the formation of cathode-anode pairs with the metal matrix was not an issue here [29,30].…”

Section: Discussionsupporting

confidence: 75%

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Anisimova

Martynenko

Новрузов

et al. 2022

Metals

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The study shows that multiaxial deformation (MAD) treatment leads to grain refinement in magnesium alloy WE43. Compared to the initial state, the MAD-processed alloy exhibited smoother biocorrosion dynamics in a fetal bovine serum and in a complete cell growth medium. Examination by microCT demonstrated retardation of the decline in the alloy volume and the Hounsfield unit values. An attendant reduction in the rate of accumulation of the biodegradation products in the immersion medium, a less pronounced alkalization, and inhibited sedimentation of biodegradation products on the surface of the alloy were observed after MAD. These effects were accompanied with an increase in the osteogenic mesenchymal stromal cell viability on the alloy surface and in a medium containing their extracts. It is expected that the more orderly dynamics of biodegradation of the WE43 alloy after MAD and the stimulation of cell colonization will effectively promote stable osteosynthesis, making repeat implant extraction surgeries unnecessary.

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Section: Discussionsupporting

confidence: 75%

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Anisimova

Martynenko

Новрузов

et al. 2022

Metals

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“…Magnesium alloys have received widespread concern over the past decade for their potential applications in biodegradable implants because of their good biocompatibility and mechanical properties, such as guided bone regeneration (GBR) for dental implants [1][2][3]. In addition to its excellent biological properties, the density of Mg (1.74 g/cm 3 ) is very close to that of human bone (1.8-2.1 g/cm 3 ) [4,5]. Magnesium alloys based on the hyper-eutectic Mg-Zn-Si ternary system have great potential application in barrier membranes for GBR due to their advantages of matched bone density, excellent wear behavior, etc.…”

Section: Introductionmentioning

confidence: 99%

Tensile Properties and Wear Resistance of Mg Alloy Containing High Si as Implant Materials

Cong¹,

Zhang²,

Zhang³

et al. 2023

Journal of Renewable Materials

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Magnesium alloy has been considered as one of the third-generation biomaterials for the regeneration and support of functional bone tissue. As a regeneration implant material with great potential applications, in-situ Mg 2 Si phase reinforced Mg-6Zn cast alloy was comprehensively studied and expected to possess excellent mechanical properties via the refining and modifying of Mg 2 Si reinforcements. The present study demonstrates that the primary and eutectic Mg 2 Si phase can be greatly modified by the yttrium (Y) addition. The size of the primary Mg 2 Si phases can be reduced to ~20 μm with an addition of 0.5 wt.% Y. This phenomenon is mainly attributed to the poisoning effect of the Y element. Moreover, wear resistance and tensile properties of the ternary alloy have also been improved by the Y addition. Mg-6Zn-4Si-0.5Y alloy exhibits optimal tensile properties and wears resistance. The ultimate tensile strength and the elongation of the alloy with 0.5 wt.% Y are 50% and 65% higher than those of the ternary alloy, respectively. Excessive Y addition (1.0 wt.%) deteriorates the tensile properties of Mg-Zn-Si alloy. The improvement of the tensile properties is mainly due to the modification of primary and eutectic Mg 2 Si phases as well as the solid solution strengthening of the Y atoms. This study provides a certain implication for the application of Mg-Zn-Si alloys containing Y elements as regeneration implants.

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“…Magnesuim (Mg) and its alloys bearing high specific strength and good biodegradeability are the widely explored green engineering materials [ 1 , 2 , 3 ]. Mg alloys exhibit low corrosion and wear and tear resistance [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Solvent Used in Development of Graphene Oxide Coating on AZ31B Magnesium Alloy: Corrosion Behavior and Biocompatibility Analysis

et al. 2022

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Clinical applications of bio-absorbable magnesium (Mg) and its alloys can be enhanced by increasing their corrosion resistance, using surface modification and functionality. In this study, we synthesized graphene oxide (GO) through improved Hummers’ method and deposited it on biodegradable AZ31B Mg alloy for further characterization. Different suspensions of GO were prepared in various solvents, like deionized water, ethanol, and acetone by ultra-sonication. Electrophoretic deposition (EPD) was used to develop GO coatings on AZ31B Mg using different GO suspensions. Effect of various solvents on corrosion behavior, as well as in vitro biocompatibility, was studied. The optimized EPD parameters were 3 volts and 90 s for coating. Different characterization techniques were used to study GO and prepared coatings. Atomic force microscopy found that the average thickness of GO was ~1 nm. Electrochemical behavior of coatings was studied through electrochemical impedance spectroscopy (EIS) and Tafel analysis in Ringer’s lactate solution. Tafel analysis revealed that GO coatings deposited by GO water suspension increased corrosion protection efficiency of AZ31B Mg alloy by ~94%. After 72 h incubation in MC3T3-E1 osteoblast cells extract, in vitro analysis was performed to determine the cell viability and biocompatibility of the GO- coated and bare Mg samples. GO coatings deposited by GO water suspension demonstrated ~2× cell viability, as well as nontoxicity and better biocompatibility compared to the bare and other GO-coated Mg samples.

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A comprehensive review on biocompatible Mg-based alloys as temporary orthopaedic implants: Current status, challenges, and future prospects

Cited by 145 publications

References 351 publications

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Tensile Properties and Wear Resistance of Mg Alloy Containing High Si as Implant Materials

Role of Solvent Used in Development of Graphene Oxide Coating on AZ31B Magnesium Alloy: Corrosion Behavior and Biocompatibility Analysis

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