A comprehensive review on biological and environmental applications of chitosan-hydroxyapatite biocomposites

Bushra, Anika; Subhani, Afia; Islam, Nafisa

doi:10.1016/j.jcomc.2023.100402

Cited by 9 publications

(4 citation statements)

References 101 publications

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“…These materials are chosen for their ability to be tailored in terms of mechanical properties and degradation rates, making them suitable for specific biomedical applications. In addition, inorganic components such as hydroxyapatite, bioactive glass, and metallic nanoparticles [12,[44][45][46][47] are integrated into hydrogels for their osteoconductivity and antibacterial properties, indicating a strong focus on composites designed for bone tissue engineering and infection control.…”

Section: Hydrogel Compositesmentioning

confidence: 99%

“…These scaffolds achieve a porous matrix that, when supplemented with glycerol and immersed in human placental extracts, becomes biologically activated, thus serving as a promising platform for bone tissue engineering [44]. Moreover, the development of chitosan-hydroxyapatite biocomposites combines the bioceramic properties of hydroxyapatite with the bioactivity of chitosan in various forms, such as scaffolds and films, catering to both bone tissue engineering and environmental bioremediation [45].…”

Section: Orthopedic and Bone Regenerationmentioning

confidence: 99%

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Hydrogel Composites for Multifunctional Biomedical Applications

Omidian,

Akhzarmehr,

Dey Chowdhury

2024

J. Compos. Sci.

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Hydrogel composites are pivotal in biomedical research, showing promise across various applications. This review aims to thoroughly examine their significance and versatile roles in regenerative medicine, tissue engineering, and drug delivery systems. Key areas of investigation include integrating growth factor delivery systems, overcoming structural limitations in tissue engineering, exploring innovations in clinical applications, and addressing challenges in achieving bioactivity and biomechanical compatibility. Furthermore, the review will discuss controlled release mechanisms for drug delivery, advancements in biocompatibility and mechanical stability, recent progress in tissue regeneration and wound healing, and future prospects such as smart hydrogels, personalized treatments, and integration with wearable technology. Ultimately, the goal is to provide a comprehensive understanding of how hydrogel composites impact biomedical research and clinical practice.

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Section: Hydrogel Compositesmentioning

confidence: 99%

Section: Orthopedic and Bone Regenerationmentioning

confidence: 99%

Hydrogel Composites for Multifunctional Biomedical Applications

Omidian,

Akhzarmehr,

Dey Chowdhury

2024

J. Compos. Sci.

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“…This necessitates the development of biocomposites (BCs) with tailored properties to suit specific applications. Biocomposites, composed of natural-fibre/particle-reinforced polymer matrixes, find diverse applications across various industries [4][5][6]. In the automotive sector [7], they contribute to the manufacturing of interior components, like door panels and dashboards, as well as exterior elements, such as body panels.…”

Section: Introductionmentioning

confidence: 99%

Towards Greener Packaging: Tapioca Starch-Based Biocomposites with Siam Weed Extract and Flax Seed Gel as Sustainable Antibacterial Packaging Material

Swapna,

Oscar,

Korte

et al. 2024

Applied Sciences

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This paper delves into the development of biocomposite (BC) packaging material from tapioca starch (TS), flax seed gel (FS), and Siam weed (SW) extract, considering the increased demand for sustainable, eco-friendly packaging materials. The BCs—BC1 (40 mL), BC2 (80 mL), and BC3 (120 mL), prepared by varying the concentration of SW—were subjected to morphological, structure, thermal, and optical characterisations. The BC with a fragmented, agglomerated morphology shows cellulosic peaks in the X-ray diffraction pattern, indicating the C-type crystalline structure in TS. Thermogravimetric analysis confirmed the BC’s safe use up to 300 °C, with a minimal 40% weight loss. Differential scanning calorimetry plots identified heat absorption during gelatinisation, with an endothermic peak at 300 °C marking a phase transition. The Fourier transform infrared (FTIR) and UV–visible spectra revealed functional groups that attribute antibacterial potential to the BC. The optical analyses show greater absorption and fewer emissions, resulting in the increased enthalpy responsible for the microbial activities. Antibacterial studies demonstrated BC2’s efficacy against Staphylococcus aureus, while the stability against humidity and the minimal weight loss underscored the BC’s robust thermal stability. FTIR spectra of post-heating at 80 °C confirmed the structural integrity, positioning the BC as a promising material for eco-friendly packaging solutions.

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“…A chitosan/M−HAP composite as potential material for biomedical and orthopedic applications. The combination of M−HAP/chitosan composite has good biocompatibility and suitable mechanical properties [53–56] . Deposition of HAP on metallic implants using various coating methods such as electrophoretic deposition, plasma spraying, sol‐gel method, sputter coating, pulsed laser deposition, and physical vapor deposition (PVD) [57,58] .…”

Section: Introductionmentioning

confidence: 99%

Development of Chitosan/Mg−Zn−HAP/ZrO₂ Bilayer Coating on Ti Alloy for Biomedical Applications

Suganthi,

Avula,

et al. 2024

ChemistrySelect

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Titanium alloys (Ti−6Al−4V) are being used in many biomedical applications due to their unique properties of bioactivity, excellent mechanical properties, low toxicity, biocompatibility, and long‐term implant application for their satisfactory corrosion resistance. We have developed a new two‐step fabrication process of zirconium oxide (ZrO2) and Chitosan/Mg−Zn−HAP (Chitosan/M−HAP) bilayer layer coating on Ti alloy for biomedical applications. Flower‐structured bilayers were coated by the electrochemical deposition method. Electrochemically deposited bilayer‐coated Ti alloy specimens were characterized by various analytical techniques like field‐emission scanning electron microscope (FE‐SEM), X‐ray diffraction (XRD), and EDS mapping analysis. Furthermore, the developed bilayer (Chitosan/Mg−Zn−HAP/ZrO2) coated Ti alloy samples improved mechanical properties such as adhesion strength (20.1±0.4 MPa) and hardness (446±4 Hv), compared to other coatings. An investigation of polarization curves showed a positive shift in the polarization values (Ecorr, and Icorr) of the Chitosan/M−HAP/ZrO2 bilayer coatings on Ti alloy. Bilayer‐modified Ti alloy samples show good antimicrobial response toward Gram‐negative and Gram‐positive bacteria. Meanwhile, the cell viability and proliferation of the bilayer‐coated samples were evaluated and the exhibited result improved cell proliferation, and bioactivity compared to other coated materials. From the results, it can be evident that the developed Chitosan/Mg−Zn−HAP/ZrO2 bilayer‐coated Ti alloy could be a good potential candidate for biomedical applications.

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A comprehensive review on biological and environmental applications of chitosan-hydroxyapatite biocomposites

Cited by 9 publications

References 101 publications

Hydrogel Composites for Multifunctional Biomedical Applications

Hydrogel Composites for Multifunctional Biomedical Applications

Towards Greener Packaging: Tapioca Starch-Based Biocomposites with Siam Weed Extract and Flax Seed Gel as Sustainable Antibacterial Packaging Material

Development of Chitosan/Mg−Zn−HAP/ZrO₂ Bilayer Coating on Ti Alloy for Biomedical Applications

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A comprehensive review on biological and environmental applications of chitosan-hydroxyapatite biocomposites

Cited by 9 publications

References 101 publications

Hydrogel Composites for Multifunctional Biomedical Applications

Hydrogel Composites for Multifunctional Biomedical Applications

Towards Greener Packaging: Tapioca Starch-Based Biocomposites with Siam Weed Extract and Flax Seed Gel as Sustainable Antibacterial Packaging Material

Development of Chitosan/Mg−Zn−HAP/ZrO2 Bilayer Coating on Ti Alloy for Biomedical Applications

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Development of Chitosan/Mg−Zn−HAP/ZrO₂ Bilayer Coating on Ti Alloy for Biomedical Applications