A Comprehensive Review on Chemotaxonomic and Phytochemical Aspects of Homoisoflavonoids, as Rare Flavonoid Derivatives

Mottaghipisheh, Javad; Stuppner, Hermann

doi:10.3390/ijms22052735

Cited by 32 publications

(22 citation statements)

References 134 publications

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“…The compounds of 3-(3′,4′-Dihydroxybenzyl)-7-hydroxychroman-4-one and 3-(4'-Hydroxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one in the ethyl acetate fraction and ethanolic fraction have several hydroxyl groups, so it is classified as a flavonoid with a flavonol skeleton [27]. Another study has isolated methylripariochromene-A from the benzene extract of Eupatorium riparium [7].…”

Section: The Anticancer Activity Of Crude Ethanolic Extract N-hexane ...mentioning

confidence: 99%

Anticancer activity and apoptotic induction of Chromolaena odorata Linn leaves extract and fractions on hepatocellular carcinoma cell lines (HepG2)

Yusuf

Fahriani

2022

J. Nat.

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The purpose of this study is to screen and to evaluate anticancer activity and apoptosis induction of Chromolaena odorata (C. odorata) leaves extract and its fractions on HepG2 cancer cell lines. The C. odorata leaves were extracted by maceration using ethanol 80% then fractionated by using n-hexane, ethyl acetate and ethanol. MTT assay method was used to evaluate anticancer activity and flowcytometri method used to evaluate the induction of apoptosis. The phytochemical analysis and characterization of the major compound of the extract and the fractions were done by using Liquid Chromatography-Mass Spectroscopy (LCMS). The phytochemical analyis showed that the crude ethanolic extract and fractions of C. odorata leaves contains alkaloid, flavonoids, phenolic, steroids, tannin and saponin. The result of LCMS shown the major compounds of the extract and fractions are 5,7,8,3′,4′-Pentamethoxyflavonone, 1-Carboethoxy-β-carboline, 3-Methylcanthin-2, 6- dion, Canthin-6-one. In the n-hexane fraction obtained 5,7,8,3′,4′-Pentamethoxyflavonone, Methyl ophiopogonanone A and Pd-C-Ⅱ. Meanwhile, in the ethyl acetate fraction contained, 3-(3′,4′-Dihydroxybenzyl)-7-hydroxychroman-4-one, 3-(4'-Hydroxy-benzyl)-5,7-dihydroxy-6-methyl-8- methoxy-chroman-4-one, Methyl opiopogonanone A and Sinensetin. The ethanol fraction, contained the compound 3-(3′,4′-Dihydroxybenzyl)-7-hydroxychroman-4-one, 3-(4'-Hydroxy-benzyl)-5,7-dihydroxy-6-methyl-8- methoxy-chroman-4-one and Methyl opiopogonanone A. The crude ethanolic extract, n-hexane fraction, ethyl acetate and ethanol fraction extract have anticancer activities with IC50 value of 23.44 mg/mL, 84.52mg/mL; 88.51mg/mL; and 167.49 mg/mL respectively. This research suggests the crude ethanolic extract of Chromolaena odorata leaves has a potential candidate for hepatocarcinoma treatment.

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Section: The Anticancer Activity Of Crude Ethanolic Extract N-hexane ...mentioning

confidence: 99%

Anticancer activity and apoptotic induction of Chromolaena odorata Linn leaves extract and fractions on hepatocellular carcinoma cell lines (HepG2)

Yusuf

Fahriani

2022

J. Nat.

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“…Classification of homoisoflavonoid is based on the structure and divided into five groups: sappanin, scillascillin, brazilin, caesalpin and protosappanin types. 14 The second most abundant compound was Protosappanin E1. This compound has molecular formula of protosappanins E1 and E2 (polymer components of hematoxylin and protosappanin).…”

Section: Lc-ms Analysismentioning

confidence: 99%

Alpha-glucosidase and DPP-IV Inhibitory Activities of Ethanol Extract from Caesalpinia sappan, Andrographis paniculata, and Syzygium cumini

Robbani¹,

Elya²,

Iswandana³

2022

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Syzygium cumini (synonym: Syzygium jambolanum or Eugenia cumini) is an original plant from India and the Asian sub-continent. Ayurvedic and Indian Folk Medicine have elaborated the use of this plant for diabetic treatment before the advent of insulin. 5 Based on the biochemical screening of methanolic and aqueous leaves extracts of Syzygium cumini, it showed that those extracts contained alkaloids, saponins, carbohydrates, flavonoids, terpenoids, glycosides and proteins. 6 Moreover, four types of flavonoid compounds are present in leaf extract of Syzygium cumini, quercetin, rutin, ellagic acid and kaempferol. The ethanolic leaf extract showed the highest quantity of quercetin. 7 Caesalpinia sappan L., commonly known as sappan wood or heartwood, is a plant of the Leguminosae family with various medicinal properties, such as skin rashes and excessive body heat, heartburn and indigestion, blood purifier, and diabetes. The pharmacological activity of sappan wood has been proven in various studies, including antioxidant, antibacterial, anti-acne, anti-inflammatory, antihypoglycemic and hepatoprotective. The most abundant water-soluble flavonoid in heartwood is Brazilin which gives red color in the extract. Therefore, sappan wood is also used as a coloring agent for the food, beverages, or textile industry. 8

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“…Homoisoflavonoids are a rare class of flavonoids present in few plant families like Fabaceae, Asparagaceae, Portulacaceae, Cucurbitaceae, and Polygonaceae [ 191 ]. Recently, it is reported in Caesalpinia sappan of the Fabaceae family disclosing potential anti-influenza activities.…”

Section: Alternate Therapiesmentioning

confidence: 99%

Substantial effect of phytochemical constituents against the pandemic disease influenza—a review

Devi

Sarala

2021

Futur J Pharm Sci

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Background Influenza is an acute respiratory tract infection caused by the influenza virus. Vaccination and antiviral drugs are the two methods opted to control the disease. Besides their efficiency, they also cause adverse side effects. Hence, scientists turned their attention to powerful herbal medicines. This review put focus on various proven, scientifically validated anti-influenza compounds produced by the plants suggested for the production of newer drugs for the better treatment of influenza and its related antiviral diseases too. Main body In this review, fifty medicinal herb phytochemical constituents and their anti-influenza activities have been documented. Specifically, this review brings out the accurate and substantiates mechanisms of action of these constituents. This study categorizes the phytochemical constituents into primary and secondary metabolites which provide a source for synthesizing and developing new drugs. Conclusion This article provides a summary of the actions of the herbal constituents. Since the mechanisms of action of the components are elucidated, the pandemic situation arising due to influenza and similar antiviral diseases can be handled promisingly with greater efficiency. However, clinical trials are in great demand. The formulation of usage may be a single drug compound or multi-herbal combination. These, in turn, open up a new arena for the pharmaceutical industries to develop innovative drugs.

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A Comprehensive Review on Chemotaxonomic and Phytochemical Aspects of Homoisoflavonoids, as Rare Flavonoid Derivatives

Cited by 32 publications

References 134 publications

Anticancer activity and apoptotic induction of Chromolaena odorata Linn leaves extract and fractions on hepatocellular carcinoma cell lines (HepG2)

Anticancer activity and apoptotic induction of Chromolaena odorata Linn leaves extract and fractions on hepatocellular carcinoma cell lines (HepG2)

Alpha-glucosidase and DPP-IV Inhibitory Activities of Ethanol Extract from Caesalpinia sappan, Andrographis paniculata, and Syzygium cumini

Substantial effect of phytochemical constituents against the pandemic disease influenza—a review

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