A Comprehensive Review on Floating Drug Delivery System (FDDS)

Bhosale, Aishwarya Rajendra; Shinde, Jitendra V.; Chavan, Rajashree S.

doi:10.22270/jddt.v10i6.4461

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Among these products, gastro-retentive drug delivery systems (GRDDS) can potentially be the most suitable forms in accordance with the technological and pharmacokinetic requirements of methylcarbamate anthelmintic drugs [10]. GRDDS are oral dosage forms able to resist gastric emptying, remaining in the stomach for a long period of time thanks to different physical processes, such as bioadhesion, swelling, or floating [9,11].…”

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confidence: 99%

Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride

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Palma

et al. 2022

IJMS

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At present, the use of benzimidazole drugs in veterinary medicine is strongly limited by both pharmacokinetics and formulative issues. In this research, the possibility of applying an innovative semi-solid extrusion 3D printing process in a co-axial configuration was speculated, with the aim of producing a new gastro-retentive dosage form loaded with ricobendazole. To obtain the drug delivery system (DDS), the ionotropic gelation of alginate in combination with a divalent cation during the extrusion was exploited. Two feeds were optimized in accordance with the printing requirements and the drug chemical properties: the crosslinking ink, i.e., a water ethanol mixture containing CaCl2 at two different ratios 0.05 M and 0.1 M, hydroxyethyl cellulose 2% w/v, Tween 85 0.1% v/v and Ricobendazole 5% w/v; and alginate ink, i.e., a sodium alginate solution at 6% w/v. The characterization of the dried DDS obtained from the extrusion of gels containing different amounts of calcium chloride showed a limited effect on the ink extrudability of the crosslinking agent, which on the contrary strongly influenced the final properties of the DDS, with a difference in the polymeric matrix toughness and resulting effects on floating time and drug release.

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Section: Introductionmentioning

confidence: 99%

Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride

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Palma

et al. 2022

IJMS

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“…Different types and concentrations of the swellable polymer were used that can swell and control the drug release rate 8 . Hence FDDS improves their bioavailability, therapeutic efficiency 9 and proffers possible reduction of the dose 10 and many pharmacokinetic advantages like maintenance of therapeutic levels, reduction of dose size and improvement of the drug's solubility that is less soluble in high pH environment 11 .…”

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2022

IJPSR

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Chlordiazepoxide is a sedative and hypnotic medication which is used to treat anxiety, insomnia, and withdrawal symptoms from alcohol and/or drug abuse. Chlordiazepoxide has a medium to the long half-life, but its metabolite is pharmacologically active and has a very long half-life. In the present work, an attempt has been made to develop effervescent floating tablets of Chlordiazepoxide. Methocel K4M, Methocel K15M & Xanthan gum were employed as polymers. All the formulations were prepared by direct compression method using 6mm flat punches. The blend of all the formulations showed a better angle of repose, bulk density, tapped density, compressibility index, and Hausner's ratio. The prepared tablets exhibited excellent hardness, friability, drug content, buoyancy lag time, duration of buoyancy, swelling index. Among all the formulations, the F7 formulation floated for more than 12 h, showed short buoyancy lag time of 96±0.92 seconds, high swelling indices of 2.4±0.12 %, and showed maximum cumulative percent drug release of 98.21±0.24 % in 12 h. Consequently, formulation F7, made using xanthan gum in 10mg/unit tablet weight concentration, was considered as an optimized formulation. The mechanism of drug release was found to be following zeroorder release kinetics and non-Fickian diffusion. INTRODUCTION:Chlordiazepoxide, a benzodiazepine derivative, is mainly employed to treat anxiety and acute alcohol withdrawal symptoms and fear before surgery 1 . Floating drug delivery systems offer gastric retentive behavior, improved drug absorption, increased gastric residence time and make the formulation spend more time at its absorption site, controlled delivery of drugs, delivered drugs for local action, and minimized mucosal irritation due to the drugs, and site-specific delivery 2 .

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Development and in Vitro/In Vivo Evaluation of Itopride Hydrochloride Expanding Tablets

et al. 2023

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Purpose Gastroretentive drug delivery systems (GRDDS) have attracted interest for enhancement of absorption and bioavailability of some drugs. Itopride hydrochloride (ITOP) is a drug used for treatment of gastroesophageal reflux and other gastric motility disorders, but is characterized by narrow absorption window and short in vivo half-life. Therefore, it is expected that its formulation in expanding gastroretentive tablets would increase its gastric residence, thus leading to decreased frequency of administration and increased patient compliance. Methods The direct compression method was used for formulation of tablets. Four different hydrophilic polymers (xanthan gum, sodium alginate, gellan gum, pectin) were screened separately with Avicel 102 and PVP k30 as excipients. The effect of different factors (polymer type and amount, and excipient amount) on the tablet properties such as hardness, friability, thickness, diameter, weight variation, swelling, and in vitro drug dissolution was studied. In addition, swelling test, accelerated stability test, and in vivo study were performed on the optimized formulation. Results Tablets prepared using xanthan gum exhibited favorable properties compared to tablets prepared using the other gums, however increasing the polymer amount led to increased tablet friability. The selected formulation exhibited obvious expansion reaching 17.45 mm and lasting for 24 h, coupled with a sustained release behavior. X-ray scans in human volunteers suggested the residence of the tablet in the stomach for a period of 6 h in fed state. Conclusion Successful preparation of directly compressible ITOP expanding tablets was achieved in this study, which is expected to result in better therapeutic outcome in gastroesophageal reflux.

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A Comprehensive Review on Floating Drug Delivery System (FDDS)

Cited by 6 publications

References 14 publications

Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride

Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride

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Development and in Vitro/In Vivo Evaluation of Itopride Hydrochloride Expanding Tablets

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