A Comprehensive Review on Food and Medicinal Prospects of Astraeus hygrometricus

Biswas, Gunjan; Nandi, Sudeshna; Kuila, Debashis; Acharya, Krishnendu

doi:10.5530/pj.2017.6.125

Cited by 16 publications

(9 citation statements)

References 50 publications

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“…Astraeus hygrometricus is a wild edible mushroom commonly found in the laterite forests near the roots of Shorea robusta trees. Its ethnomedicinal role has been documented in preventing several diseases . We have recently isolated a novel triterpene, astrakurkurone, from A. hygrometricus and partially characterized it .…”

Section: Introductionmentioning

confidence: 99%

Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl‐2 family proteins

et al. 2019

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Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent “target‐specific” drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus hygrometricus. We have discussed the structure and stability of astrakurkurone employing single‐crystal X‐ray crystallography and studied its potential apoptogenicity in hepatocellular carcinoma (HCC) cells. Our experiments reveal that it is cytotoxic against the HCC cell lines (Hep 3B and Hep G2) at significantly low doses. Further investigations indicated that astrakurkurone acts by inducing apoptosis in the cells, disrupting mitochondrial membrane potential and inducing the expression of Bcl‐2 family proteins, for example, Bax, and the downstream effector caspases 3 and 9. A molecular docking study also predicted direct interactions of the drug with antiapoptotic proteins Bcl‐2 and Bcl‐xL. Thus, astrakurkurone could become a valuable addition to the conventional repertoire of future anticancer drugs. © 2019 IUBMB Life, 1–11, 2019

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Section: Introductionmentioning

confidence: 99%

Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl‐2 family proteins

et al. 2019

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“…Recent scientific investigations on different mushrooms extract and their metabolites revealed its importance in the treatment of different human ailments (67)(68)(69)(70)(71)(72)(73) . Here, the hepatoprotective properties of different mushrooms are documented below.…”

Section: Natural Strategy For Hepatoprotectionmentioning

confidence: 99%

Include mushroom in daily diet—A strategy for better hepatic health

Chatterjee

Acharya

2015

Food Reviews International

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Liver, the most important metabolic organ of the body is also the major organ for the detoxification of the blood stream. If the accumulation of toxins is faster than their removal by liver, hepatic damage occurs. Although synthetic drugs are available in the market, long term use of such drugs has consequential side effects. Therefore, the growing need to find safe, costeffective drugs devoid of adverse effects is spawning extensive research. Mushrooms are rising as a major medicinal food and pharmaceuticals. This review summarizes the medicinal value of different edible mushrooms on free radical, xenobiotic and drug induced hepatotoxicity.

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“…Although there are many reports on the morphology, photochemistry and nutritional property of Astraeus , little is known about the effect of bacteria on the growth and development of mushrooms of Astraeus . This may be one of the reasons that, despite nearly a decade of research, attempts to cultivate Astraeus have largely been unsuccessful ( Trappe 1967 , Petcharat 2003 , Biswas et al 2017 , Biswas et al 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Cataloguing the bacterial diversity in the active ectomycorrhizal zone of Astraeus from a dry deciduous forest of Shorea

Vishal

Munda

Singh

et al. 2021

BDJ

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The plant microbiome has been considered one of the most researched areas of microbial biodiversity, yet very little information is available on the microbial communities prevailing in the mushroom's ectomycorrhizosphere. Ectomycorrhizal symbioses often result in the formation of a favourable niche which enables the thriving of various microbial symbionts where these symbionts endorse functions, such as quorum sensing, biofilm formation, volatile microbial compound (VOC) production, regulation of microbial gene expression, symbiosis and virulence. The identification of hidden uncultured microbial communities around the active ectomycorrhizal zone of Astraeus from dry deciduous sal forest of Jharkhand, India was carried out using MinION Oxford Nanopore sequencing of 16S rRNA amplicons genes. High richness of Operational Taxonomic Units (1,905 OTUs) was observed. We recorded 25 distinct phyla. Proteobacteria (36%) was the most abundant phylum, followed by Firmicutes (28%), Actinobacteria (10%) and Bacteroidetes (6%), whereas Gammaproteobacteria was the most abundant class of bacterial communities in the active ectomycorrhizal zone. The ectomycorrhizosphere soil has abundant phosphate-solubilising bacteria (PSB). This is the first report of the ectomycorrhizosphere microbiome associated with Astraeus.

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A Comprehensive Review on Food and Medicinal Prospects of Astraeus hygrometricus

Cited by 16 publications

References 50 publications

Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl‐2 family proteins

Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl‐2 family proteins

Include mushroom in daily diet—A strategy for better hepatic health

Cataloguing the bacterial diversity in the active ectomycorrhizal zone of Astraeus from a dry deciduous forest of Shorea

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