A comprehensive review on lactoferrin: a natural multifunctional glycoprotein

Shini, V S; Nisha, P.

doi:10.1039/d2fo02371g

Cited by 15 publications

(4 citation statements)

References 130 publications

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“…For instance, β-lactoglobulin (Lg), the primary component of whey proteins, has shown the stimulation of certain cell proliferation, along with antioxidant [ 74 ] and immunostimulatory properties [ 75 ]. Lactoferrin (Lf) demonstrates immunomodulatory effects in the innate and adaptive immune response, regulating antibody production and T and B-cell maturation and increasing the percentage of NK cells in the lymphocyte population [ 76 ]. Lf has the ability to bind to endotoxins, thereby reducing the production of proinflammatory cytokines [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lactoferrin (Lf) demonstrates immunomodulatory effects in the innate and adaptive immune response, regulating antibody production and T and B-cell maturation and increasing the percentage of NK cells in the lymphocyte population [ 76 ]. Lf has the ability to bind to endotoxins, thereby reducing the production of proinflammatory cytokines [ 76 ]. Moreover, Lf enhances the chemotaxis of B, T, and bone marrow-derived dendritic cells toward specific chemokine ligands, indicating its role in immune cell recruitment.…”

Section: Discussionmentioning

confidence: 99%

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Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review

Golonko,

Pienkowski,

Swislocka

et al. 2024

Cell Death Dis

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Immunotherapy is emerging as a promising avenue in oncology, gaining increasing importance and offering substantial advantages when compared to chemotherapy or radiotherapy. However, in the context of immunotherapy, there is the potential for the immune system to either support or hinder the administered treatment. This review encompasses recent and pivotal studies that assess the influence of dietary elements, including vitamins, fatty acids, nutrients, small dietary molecules, dietary patterns, and caloric restriction, on the ability to modulate immune responses. Furthermore, the article underscores how these dietary factors have the potential to modify and enhance the effectiveness of anticancer immunotherapy. It emphasizes the necessity for additional research to comprehend the underlying mechanisms for optimizing the efficacy of anticancer therapy and defining dietary strategies that may reduce cancer-related morbidity and mortality. Persistent investigation in this field holds significant promise for improving cancer treatment outcomes and maximizing the benefits of immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review

Golonko,

Pienkowski,

Swislocka

et al. 2024

Cell Death Dis

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“…According to previous studies [26,27] and our CCK-8 assay (Figure 1), the ethanol stimulation dose was set at 400 mM. Because 400 mM of ethanol induced a mild injury in the BRL-3A cells, which was possibly prevented by the Lf treatment, it might be hard for Lf, as a natural product [28], to alleviate more severe injuries induced by higher doses of ethanol. Lf at a concentration of 400 µg/mL not only did not induce cytotoxicity but also rescued the ethanol-induced cell viability decrease (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells

Li,

Ding,

Yan

et al. 2023

IJMS

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Our previous animal studies found that the preventive effects of lactoferrin (Lf) on alcoholic liver injury (ALI) are associated with nuclear factor E2-related factor 2 (Nrf2). To further explore the causality, experiments were performed using rat normal liver BRL-3A cells. Lf treatment reduced ethanol-induced death and apoptosis; meanwhile, Lf treatment alleviated excessive LDH release. These findings confirmed the protection of Lf against ethanol-induced injury in BRL-3A cells. Mechanistically, Lf treatment reversed the reduction in nuclear Nrf2 induced by ethanol without affecting the cytoplasmic Nrf2 level, which led to antioxidant enzyme activity restoration. However, the blocking of Nrf2 nuclear translocation by ML385 eliminated the protective effects of Lf. In a conclusion, Lf protects BRL-3A cells from ethanol-induced injury via promoting Nrf2 nuclear translocation.

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“…To dissect the prebiotic ability of LF and LF-related peptides, it is necessary to first describe their antibacterial activities. Although LF is known to have various protective functions in the mammalian body [ 37 , 38 , 39 , 40 ], its antimicrobial activity has been the most studied feature [ 41 ]. The mechanisms of the antimicrobial activities of LF, LFcins, and other LF-derived peptides have been well elucidated and reviewed in some studies [ 5 , 42 , 43 ].…”

Section: Contrasting Antibacterial Effects Of Lactoferrins On Pathoge...mentioning

confidence: 99%

Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control

Liu

Chen

2023

Nutrients

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Lactoferrin (LF) is a glycoprotein found in mammalian milk, and lactoferricin is a peptide derived from LF hydrolysate. Both LF and lactoferricin (LFcin) have diverse functions that could benefit mammals. Bovine LF (BLF) and BLFcin exhibit a wide range of antimicrobial activities, but most probiotic strains are relatively resistant to their antibacterial effects. BLF and BLF hydrolysate can promote the growth of specific probiotics depending on the culture conditions, the dose of BLF or BLF-related peptides, and the probiotic strains used. BLF supplementation has been shown to modulate several central molecular pathways or genes in Lacticaseibacillus rhamnosus GG under cold conditions, which may explain the prebiotic roles of BLF. LF alone or in combination with selected probiotics can help control bacterial infections or metabolic disorders, both in animal studies and in human clinical trials. Various LF-expressing probiotics, including those expressing BLF, human LF, or porcine LF, have been developed to facilitate the combination of LFs with specific probiotics. Supplementation with LF-expressing probiotics has positive effects in animal studies. Interestingly, inactivated LF-expressing probiotics significantly improved diet-induced nonalcoholic fatty liver disease (NAFLD) in a mouse model. This review highlights the accumulated evidence supporting the use of LF in combination with selected LF-resistant probiotics or LF-expressing probiotics in the field.

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A comprehensive review on lactoferrin: a natural multifunctional glycoprotein

Abstract: Lactoferrin (Lf) is a natural iron-binding globular glycoprotein, present mainly in milk. It maintains human health through its multifunctional activities including immunomodulation, iron metabolism, antioxidant and prebiotic efficacy. It also...

Cited by 15 publications

References 130 publications

Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review

Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review

Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells

Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control

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